BIOLOGY
5th Edition
ISBN: 9781264104680
Author: BROOKER
Publisher: MCG
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Chapter 6.2, Problem 1EQ
Summary Introduction
To determine: The reason that it is essential to purify individual subunits of RNase P to show that it is a ribozyme.
Introduction: RNase P acts as a catalyst during the processing of transfer RNA (Ribose
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Chapter 6 Solutions
BIOLOGY
Ch. 6.1 - Which do you think has more entropy, a NaCl...Ch. 6.1 - Prob. 2CCCh. 6.2 - Prob. 1CCCh. 6.2 - Prob. 2CCCh. 6.2 - Prob. 1CSCh. 6.2 - Prob. 1EQCh. 6.2 - Prob. 2EQCh. 6.2 - Prob. 3EQCh. 6.3 - Prob. 1CSCh. 6.3 - Prob. 2CS
Ch. 6.4 - What are advantages of protein degradation?Ch. 6 - Reactions that release free energy are a....Ch. 6 - Enzymes speed up reactions by a. providing...Ch. 6 - Prob. 3TYCh. 6 - Researchers analyzed a cell extracta mixture of...Ch. 6 - In biological systems, ATP functions by a....Ch. 6 - In a chemical reaction, NADH is converted to NAD+...Ch. 6 - Prob. 7TYCh. 6 - Prob. 8TYCh. 6 - Prob. 9TYCh. 6 - Autophagy provides a way for cells to a. degrade...Ch. 6 - Prob. 1CQCh. 6 - Prob. 2CQCh. 6 - Prob. 3CQCh. 6 - Prob. 1COQCh. 6 - Prob. 2COQ
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- The Shine-Dalgarno Sequence is used in bacteria eukaryotes botharrow_forwardThe ribosome can transfer any peptidyl group from the P-site tRNA to any aminoacyl group on the A-site RNA, but the rate may vary with the identities of those groups. Propose an explanation why the ribosome synthesizes poly-Pro sequences extremely slowly compared to other peptide sequences.arrow_forwardBriefly explain the importance of the protein factor EF-Ts in the translation process. Do not simply define the given.arrow_forward
- You are an expert in RNA structural and functional studies and your next big target is to create a new ribozyme with a ubiquitin ligase activity. You are free to look up into web-based sources, textbooks, and your notes to get required inspiration towards this end. You are expected to provide an outline for the steps involved in the ribozyme production process along with the list of materials needed.arrow_forwardThe antibacterial protein colicin E3 is an effective inhibitor of protein synthesis in bacteria. This protein is a nuclease, specifically attacking a phos- phodiester bond near the 3' end of the 16S RNA. Suggest a mechanism for the effect of colicin E3 on translation.arrow_forwardSite-directed mutagenesis of enzyme active site explainedarrow_forward
- Rifamycins have been used for the treatment of many diseases, including HIV-related Tuberculosis. Explain how Rifamycins inhibit the activities of bacterial DNA dependent RNA polymerase.arrow_forwardBudding yeasts such as S. cerevisiae exhibit telomerase activity throughout their life cycles, whereas human somatic cells do not exhibit telomerase activity. Suggest why this is so.arrow_forwardTreating a solution of ribonuclease with 2-mercaptoethanol and urea denatures the enzyme. If the 2-mercaptoethanol is removed, followed by the removal of urea, the ability of the enzyme solution to hydrolyse RNA is reduced by about 99%. What is the most plausible explanation for this observation? a. All of the RNase molecules have about 1% of their usual activity, due to changes to the organisation of disulphide bonds b. Random formation of disulphide bonds mean about 1% of the RNase molecules are 100% active whereas 99% have no activity c. Deprotonation of histidine in the active site of the enzyme means that only about 1% of the enzyme molecules are active d. Deprotonation of histidine in the active site of the enzyme means that all of the enzyme molecules have 1% of their usual activityarrow_forward
- Explain how the use of radiolabeled amino acids in this procedure helped to reveal the genetic code.arrow_forwardWhy RNase H cannot remove all the RNA residue from Okazaki fragments to form a lagging strand? Explain.arrow_forwardBriefly explain the importance of the 5'-cap in the translation process. Do not simply define the given.arrow_forward
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