Bio 121 Campbell Biology Truman College
Bio 121 Campbell Biology Truman College
17th Edition
ISBN: 9781323670637
Author: Urry, Cain
Publisher: PEARSON
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Chapter 6.7, Problem 3CC

MAKE CONNECTIONS Ø The polypeptide chain that makes up a tight junction weaves back and forth through the membrane four times, with two extracellular loops, and one loop plus short C-terminal and N-terminal tails in the cytoplasm. Looking at Figure 5.14, what would you predict about the amino acid sequence of the tight junction protein?

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Create a ROUGH SKETCH (no need for exact hydropathy indices and residue numbers) of the hydropathy plot for the given membrane protein. -coo Please follow the color assignment of the helical domains and properly label the plot and axes. Here is an example: Amino Outside terminus Transmembrane helices are predicted by hydrophobic stretches of 20-25 aa residues 10 50 100 150 200 250 Hydrophobic Inside Hydrophilic Carboxyl terminus -3 10 50 100 150 200 250 Residue number Bacteriorhodopsin Hydropathy index
Membrane Protein Insertion in the ER This figure displays five small hypothetical proteins. The a-helix secondary structure of the protein is bracketed and the number of amino acids in the helix is indicated. If the hypothetical ER localization sequence is green-yellow-yellow-green-yellow-red, what protein could potentially be a transmembrane protein in the plasma membrane? = Acidic = Basic = Polar (uncharged) O = Hydrophobic CO₂ T 20 CO2 T 20 NH₂ A. T 20 NH₂ B. NH₂ C. T 20 NH₂ D. NH₂ E. tot 10
Researchers have discovered a new membrane protein that has three transmembrane domain αhelixes that span the lipid bilayer.a. If the lipid bilayer is 30 Å thick, what is the smallest number of amino acid residues thatcan be in each α-helixes for them to be long enough to span the bilayer?

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