Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
bartleby

Concept explainers

bartleby

Videos

Question
Book Icon
Chapter 7, Problem 1P
Interpretation Introduction

Interpretation: The physiological effect predicted from a mutation that replaced with serine the cysteine in the constant part of immunoglobulin light chain and involved in disulfide-bond formation with the heavy chain should be explained.

Concept Introduction: There is a disulfide linkage between the cysteine amino acids that holds light chain in association with the heavy chain of the immunoglobulin.

  Biochemistry: Concepts and Connections (2nd Edition), Chapter 7, Problem 1P

Expert Solution & Answer
Check Mark

Answer to Problem 1P

Solution: Because of the cysteine to serine mutation there will be no disulfide linkage between the light and heavy chain of the immunoglobulin.

Explanation of Solution

The cysteine helps in disulfide linkage formation between the light and heavy chain in the Fab fragment of the immunoglobulin. In the absence of cysteine, serine will not be able to form disulfide linkage between the light and heavy chain of the immunoglobulin. As a result of this mutation the light and heavy chain of the immunoglobulin will not stay physically connected to each other. This will cause the immunoglobulin to denature.

Conclusion

Thus, because of the cysteine to serine mutation there will be no disulfide linkage between the light and heavy chain of the immunoglobulin.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!
Knowledge Booster
Background pattern image
Biochemistry
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.
Recommended textbooks for you
Text book image
Biochemistry
Biochemistry
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:W. H. Freeman
Text book image
Lehninger Principles of Biochemistry
Biochemistry
ISBN:9781464126116
Author:David L. Nelson, Michael M. Cox
Publisher:W. H. Freeman
Text book image
Fundamentals of Biochemistry: Life at the Molecul...
Biochemistry
ISBN:9781118918401
Author:Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:WILEY
Text book image
Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning
Text book image
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Text book image
Fundamentals of General, Organic, and Biological ...
Biochemistry
ISBN:9780134015187
Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:PEARSON
Immune System and Immune Response Animation; Author: Medical Sciences Animations;https://www.youtube.com/watch?v=JDdbUBXPKc4;License: Standard YouTube License, CC-BY
Immune response: summary; Author: Dr Bhavsar Biology;https://www.youtube.com/watch?v=ADANgHkX4OY;License: Standard Youtube License