Study Guide and Solutions Manual for Essentials of Genetics
9th Edition
ISBN: 9780134189987
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Harry Nickla
Publisher: PEARSON
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Chapter 7, Problem 4CS
CASE STUDY | Links to autism
As parents of an autistic child, a couple decided that entering a research study would not only educate them about their son's condition, but also help further research into this complex, behaviorally defined disorder. In an interview, researchers explained to the parents that autism results from the action of hundreds of genes and that no single gene accounts for more than a small percentage of cases. Recent studies have identified 18 genes that have a higher likelihood of involvement, referred to as candidate genes; three of these, on chromosomes 2, 7, and 14, are regarded as very strong candidate genes. Generally unaware of the principles of basic genetics, the couple asked a number of interesting questions. If you were the interviewer, how would you respond to them?
Is prenatal diagnosis for autism possible?
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Please answer all questions if possible.
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2. Why would a researcher be interested in over- or mis- expression phenotypes?
The role of the TPMT genotype in response to treatment emphasizes the importance of pharmacogenomics. What changes in treatment would be recommended for someone homozygous recessive for TPMT, compared to someone that is homozygous dominant?
Give a schematic diagram of how we can Treatment Down's syndrome by using gene therapy? Please answer at your own words,please..
Chapter 7 Solutions
Study Guide and Solutions Manual for Essentials of Genetics
Ch. 7 -
CASE STUDY | Links to autism
As parents of an...Ch. 7 -
CASE STUDY | Links to autism
As parents of an...Ch. 7 - CASE STUDY | Links to autism As parents of an...Ch. 7 -
CASE STUDY | Links to autism
As parents of an...Ch. 7 -
HOW DO WE KNOW?
1. In this chapter, we focused on...Ch. 7 -
CONCEPT QUESTION
2. Review the Chapter Concepts...Ch. 7 - Describe the cytological observation that suggests...Ch. 7 - Why does more crossing over occur between two...Ch. 7 - Why is a 50 percent recovery of single-crossover...Ch. 7 - Why are double-crossover events expected less...
Ch. 7 - What is the proposed basis for positive...Ch. 7 - What three essential criteria must be met in order...Ch. 7 - The genes dumpy wings (dp), clot eyes (cl), and...Ch. 7 - Colored aleurone in the kernels of corn is due to...Ch. 7 - In the cross shown here, involving two linked...Ch. 7 - In a series of two-point map crosses involving...Ch. 7 -
13. Two different female Drosophila were...Ch. 7 -
14. In Drosophila, a cross was made between...Ch. 7 -
15. A cross in Drosophila involved the recessive,...Ch. 7 -
16. Drosophila melanogaster has one pair of sex...Ch. 7 -
17. Drosophila females homozygous for the third...Ch. 7 - In Drosophila, the two mutations Stubble bristles...Ch. 7 -
19. A female of genotype
produces 100 meiotic...Ch. 7 - In a plant, fruit color is either red or yellow,...Ch. 7 - In Drosophila, Dichaete (D) is a mutation on...Ch. 7 - An organism of the genotype AaBbCc was testcrossed...Ch. 7 - Based on our discussion of the potential...Ch. 7 - Prob. 24PDQCh. 7 - DNA markers have greatly enhanced the mapping of...Ch. 7 - Are sister chromatid exchanges effective in...
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- Please answer all questions if possible. What do loss of function alleles tell us about normal gene function? Why would a researcher be interested in over- or mis-expression phenotypes? Why are genetic screens useful? Why do biologists do screens? What are we trying to do? What is the Big Picture purpose?arrow_forwardGive a schematic diagram of how we can Treatment Down Syndrome by using gene therapy? Please answer at your own words,please..arrow_forwardDraw a schematic diagram of how we can Treatment Parkinson's disease by using gene therapy? Please answer at your own words,please..arrow_forward
- 1. What role does a patient's genetics have in their symptoms of muscular dystrophy? What causes various mutations to cause distinct symptoms? (two to three sentences) (Think about why various mutations in different genes cause different illnesses.)2. What can family history teach you about a patient's muscular dystrophy inheritance and, hence, genetic basis? (two to three sentences)3. The X-chromosome contains the mutation that causes Duchenne Muscular Dystrophy (DMD). Explains how this impacts DMD inheritance and why DMD patients are disproportionately male. (two to three sentences)arrow_forwardMany genetic counselors will not provide presymptomatic genetic testing for Huntington disease to people below the age of 18. Why are there concerns about offering this and many other genetic tests to minors? What types of presymptomatic genetic testing might be appropriate for minors?arrow_forward1A. Fruit Flies and Genetics Research: Imagine you are working in a genetics lab with the fruit fly Drosophila melanogaster, a model organism for genetics research. You want to determine whether a trait you have discovered in fruit flies is dominant or recessive.• Explain how you would design an experiment to answer this question.• Predict what types of outcomes are possible. Which would indicate that the trait is dominant? Which would indicate that it is recessive? 1.B Model Genetic Organisms: Why are fruit flies considered a model genetic organism? Would humans fit this description?arrow_forward
- Fragile X syndrome why is interesting Fragile X syndrome What are the symptoms or characteristics of this disorder or trait? What is the prevalence of the trait or disorder? What are the main genetic factors? s the genetic cause of this disorder or trait known? What gene(s) have been proven to be involved? Or, if not known, what genes are thought to be involved? Is it caused by a single gene? polygenic? Multifactorial? Devote a few paragraphs to this This could be one of the longest parts of the paper, if you choose to focus on this. If multiple genes are thought to be involved, discuss the specific role of at least one of them in depth (if known). Is the gene you’re discussing thought to play a major or a minor role in the phenotype? What chromosome is it on? What protein does it code for, and how might the protein possibly contribute to the phenotype? If no genes have yet been identified, indicate this, and devote at least one paragraph to any current efforts to determine which…arrow_forwardInterested in exploring the genetic pathways that lead to neurological issues, you want to see if recessive mutations which generate too many neurons (tm) in flies - which many causes autistic like symptoms are in the same gene as mutations that generate too few neurons (tf) - intellectual diabilities. You cross a true-breeding homozygous tm/tm fly to a homozygous too few neuron fly tf/tf. What phenotype in the progeny would tell these mutations are in different genes?arrow_forwardHow can you envision using this new information? Discuss how things that we do to our bodies (smoking, recreational drugs, employment environments, stress levels, eating/drinking habits, etc.) can influence genetic expression in our future child(ren).arrow_forward
- The ability of humans to taste the bitter chemical phenylthiocarbamide (PTC) is a genetic trait. People with at least one copy of the normal, dominant allele of the PTC gene can taste PTC; those who are homozygous for a mutant, recessive allele cannot taste it. Could two parents able to taste PTC have a nontaster child? Could nontaster parents have a child able to taste PTC? A pair of taster parents, both of whom had one parent able to taste PTC and one nontaster parent, are expecting their first child. What is the chance that the child will be able to taste PTC? Unable to taste PTC? Suppose the first child is a nontaster. What is the chance that their second child will also be unable to taste PTC?arrow_forward1) Perception of a bitter taste from phenylthiocarbamide (PTC) is dominant (T) to not being able to taste PTC. Albinism is recessive to normal pigmentation (A). The genes controlling these traits are on separate chromosomes. a. A normally pigmented woman who cannot taste PTC has a father who is an albino taster, marries a many homozygous for normal pigmentation who is a PTC taster, but whose mother did not taste PTC. What are the genotypes of the woman and man listed here? b. Assuming the man and woman in the above section have children, what percentage of these children will be albino? c. What percentage of these children will have the same phenotype as their mother?arrow_forwardHow we can Treatment Parkinson's disease by using gene therapy? Please answer at your own words,please..arrow_forward
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY