Connect Access Card for Biology: Concepts and Investigations
4th Edition
ISBN: 9781259870033
Author: Mariëlle Hoefnagels Dr.
Publisher: McGraw-Hill Education
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Question
Chapter 8, Problem 13WIO
Summary Introduction
To determine:
The mutation in the gene encoding p53 be associated with high risk for cancer.
Concept Introduction:
Gene p53 is also called as the tumor protein that code for a protein that regulates the cell cycle and thus, functions as tumor suppression. It plays an important role in multicellular organisms to suppress cancer. This gene is located on the seventeenth chromosomes. It is the phosphorylated protein made up of 393 amino acids.
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Chapter 8 Solutions
Connect Access Card for Biology: Concepts and Investigations
Ch. 8.1 - Explain the roles of mitotic cell division,...Ch. 8.1 - Prob. 2MCCh. 8.2 - Prob. 1MCCh. 8.2 - Prob. 2MCCh. 8.2 - Prob. 3MCCh. 8.2 - Prob. 4MCCh. 8.2 - Prob. 5MCCh. 8.3 - Which cell types divide by binary fission?Ch. 8.3 - Prob. 2MCCh. 8.4 - Prob. 1MC
Ch. 8.4 - Sketch and label the main parts of a duplicated...Ch. 8.5 - Prob. 1MCCh. 8.5 - Prob. 2MCCh. 8.5 - Prob. 3MCCh. 8.5 - Distinguish between mitosis and cytokinesis.Ch. 8.6 - Prob. 1MCCh. 8.6 - Prob. 2MCCh. 8.6 - Prob. 3MCCh. 8.6 - Prob. 4MCCh. 8.6 - List and describe the three most common cancer...Ch. 8.6 - Prob. 6MCCh. 8.6 - Prob. 7MCCh. 8.7 - Prob. 1MCCh. 8.7 - Prob. 2MCCh. 8.8 - Prob. 1MCCh. 8.8 - Prob. 2MCCh. 8 - A DNA molecule is placed in a test tube containing...Ch. 8 - Prob. 2MCQCh. 8 - Prob. 3MCQCh. 8 - Prob. 4MCQCh. 8 - Prob. 5MCQCh. 8 - Prob. 1WIOCh. 8 - Write and explain an analogy for each of these DNA...Ch. 8 - Prob. 3WIOCh. 8 - Obtain a rubber band and twist it as m any times...Ch. 8 - Sketch and describe the events that occur when a...Ch. 8 - Prob. 6WIOCh. 8 - Prob. 7WIOCh. 8 - Describe what will happen to a cell if interphase...Ch. 8 - List the ways that binary fission is similar to...Ch. 8 - Prob. 10WIOCh. 8 - Prob. 11WIOCh. 8 - Why do chemotherapy and radiation sometimes kill...Ch. 8 - Prob. 13WIOCh. 8 - Prob. 1PITCh. 8 - Prob. 2PITCh. 8 - Prob. 3PIT
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- Explain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and how might gene therapy or other drug interventions inhibit the growth of a tumor?arrow_forwardHow can a mutation in a tumor-suppressor gene contribute to the development of cancer?arrow_forwardA mutation in p53 promoter that prevents p53 from being expresses Causes? Why? A. Increased proliferation B. Decreased proliferationarrow_forward
- Can we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb? If so, how is this possible?arrow_forwardNormal p53 is a tumor suppressor gene, when mutated it loses this function. Explain how a tissue expressing normal p53 would lose control and have over-proliferation of the cells based on p53 levels.arrow_forwardThe p53 gene encodes a tumor-suppressor protein, p53, which acts as a transcription factor for several genes. Discuss an example of a specific gene that is activated by p53 and how this gene activation will lead to a pause in the cell cycle for DNA repair to take place.arrow_forward
- explain how p53 functions in a cell that sustained DNA damage to prevent progression of that cell into a cancer cellarrow_forwardDescribe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?arrow_forwardp53 can trigger apoptosis if certain cell-cycle events fail. How does this regulatory outcome benefit a multicellular organism?arrow_forward
- How does the dysregulation of cell cycle checkpoints contribute to the development of cancer?arrow_forwardWhat is cancer? What defects are commonly found in cancer cells? Do all cancer cells have mutations in the same genes? Explain.arrow_forwardWhat does cancer drugs play in interrupting mitosis of cancer cells? How do these drugs do that?arrow_forward
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