ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260406092
Author: HARTWELL, Leland, HOOD, Leroy, Goldberg, Michael
Publisher: Mcgraw-hill Education/stony Brook University
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Chapter 8, Problem 14P
Summary Introduction
a.
To determine:
The reason for the discrepancy between the physical map and genetic map of E.coli’s trpA gene.
Introduction:
The physical map and genetic map depicts the arrangement of base pairs and genes on a chromosome. The physical map represents the complete genome sequence, and the genetic map represents the recombinant sequences.
Summary Introduction
b.
To determine:
The region on the trpA gene which shows the highest and lowest recombination frequency.
Introduction:
Crossing over or recombination between the genes of a chromosome depends on the distance between the two genes.
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Chapter 8 Solutions
ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
Ch. 8 - For each of the terms in the left column, choose...Ch. 8 - Match the hypothesis from the left column to the...Ch. 8 - How would the artificial mRNA 5GUGUGUGU . . . 3 be...Ch. 8 - An example of a portion of the T4 rIIB gene in...Ch. 8 - Consider Crick and Brenners experiments in Fig....Ch. 8 - The HbSsickle-cell allele of the human -globin...Ch. 8 - The following diagram describes the mRNA sequence...Ch. 8 - The amino acid sequence of part of a protein has...Ch. 8 - The results shown in Fig. 8.5 may have struck you...Ch. 8 - Identify all the amino acid-specifying codons in...
Ch. 8 - Before the technology existed to synthesize RNA...Ch. 8 - A particular protein has the amino acid sequence...Ch. 8 - How many possible open reading frames frames...Ch. 8 - Prob. 14PCh. 8 - Charles Yanofsky isolated many different trpA-...Ch. 8 - The sequence of a segment of mRNA, beginning with...Ch. 8 - You identify a proflavin-generated allele of a...Ch. 8 - Using recombinant DNA techniques which will be...Ch. 8 - Describe the steps in transcription that require...Ch. 8 - Chapters 6 and 7 explained that mistakes made by...Ch. 8 - The coding sequence for gene F is read from left...Ch. 8 - If you mixed the mRNA of a human gene with the...Ch. 8 - Prob. 23PCh. 8 - The Drosophila gene Dscam1 encodes proteins on the...Ch. 8 - Describe the steps in translation that require...Ch. 8 - Locate as accurately as possible the listed items...Ch. 8 - Concerning the figure for Problem 26: a. Which...Ch. 8 - a. Can a tRNA exist that has the anticodon...Ch. 8 - For parts a and b of Problem 28, consider the DNA...Ch. 8 - Remembering that the wobble base of the tRNA is...Ch. 8 - Prob. 31PCh. 8 - The yeast gene encoding a protein found in the...Ch. 8 - The sequence of a complete eukaryotic gene...Ch. 8 - Arrange the following list of eukaryotic gene...Ch. 8 - Prob. 35PCh. 8 - The human gene for 2 lens crystallin has the...Ch. 8 - In prokaryotes, a search for genes in a DNA...Ch. 8 - a. The genetic code table shown in Fig. 8.2...Ch. 8 - a. Very few if any eukaryotic genes contain tracts...Ch. 8 - Explain how differences in the initiation of...Ch. 8 - Do you think each of the following types of...Ch. 8 - Null mutations are valuable genetic resources...Ch. 8 - The following is a list of mutations that have...Ch. 8 - Considering further the mutations described in...Ch. 8 - Adermatoglyphia described previously in Problem 18...Ch. 8 - Prob. 46PCh. 8 - You learned in Problem 21 in Chapter 7 that the...Ch. 8 - When 1 million cells of a culture of haploid yeast...Ch. 8 - Why is a nonsense suppressor tRNATyr, even though...Ch. 8 - A mutant B. adonis bacterium has a nonsense...Ch. 8 - You are studying mutations in a bacterial gene...Ch. 8 - Another class of suppressor mutations, not...Ch. 8 - Yet another class of suppressor mutations not...Ch. 8 - At least one nonsense suppressing tRNA is known...Ch. 8 - An investigator was interested in studying UAG...Ch. 8 - Prob. 56PCh. 8 - In certain bacterial species, pyrrolysine Pyl,...Ch. 8 - Canavanine is an amino acid similar to arginine...
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- a. Determine the gene order, the recombination frequency between the adjacent genes, the coefficient of coincidence, and the interference. b. Explain why, in this example, the recombination frequencies are not good estimates of the map distance.arrow_forward8) Consider the observed recombination frequencies between the following linked alleles ... A-B: 13.1% B-C: 6.4% A-C: 19.5% Based on this information, construct a linkage map to illustrate the relative positions of these alleles along the same chromosome. Indicate the distances in MAP UNITS between each allele locus.arrow_forwardExplain the reason why a dicentric chromosome is unstable.arrow_forward
- 5) Cystic fibrosis is caused by a gene on chromosome 7 and results in the build-up of mucus in the lungs. Two parents who do not have cystic fibrosis have three children with the disease. What is the probability that their fourth child will also have cystic fibrosis? Explain.arrow_forwarda) Are the genes linked? Please explain SPECIFICALLY how you can distinguish between linked and unlinked genes in this instance. b) If the two genes are linked, calculate the % recombination between ser and thr. Show the formula used, as well as all of your calculations. c) Draw a single map illustrating the arrangement of the two genes on the chromosome with respect to each other and to the centromere of the chromosome. Make sure to map ALL three distances.arrow_forwardDescribe two forms of genetic recombination. What functions do they fulfill?arrow_forward
- a. What letters are used to represent the short andlong arms of human chromosomes?b. Sketch a schematic diagram of a hypothetical chromosome 3 that has 3 regions with 2 bands each on the short arm and 5 regions with 3 bands each onthe long arm. Label the arms, regions, and bandsand indicate a gene at position 3p32.arrow_forwardA normal appearing female infant was identified with a positive newborn screen, linked to chromosome 12. Few years ago, her older sibling had developed profound hypoglycemia, liver failure leading to coma, and subsequent irreparable brain damage, following a viral illness. The sibling was subsequently shown by clinical testing to have the same disorder that this female infant is screened positive for. a. What is the most likely diagnosis? b. What biomarkers would confirm this on the newborn screening process? Describe the mechanism that causes this metabolic defect.arrow_forwardInversions are known to affect crossing-over. The following homologs have the indicated order (the filled and open circles indicate centromeres): • (A B C D E) o (A D C B E) a. Considering the position of the centromere, what is this sort of inversion called?arrow_forward
- The recombination frequency in a cross can never exceed 50%. Explain why is this limit?arrow_forwardIn com, male sterility is controlled by maternal cytoplasmic elements. However, the presence of a nuclear fertility restorer gene (F_) restores fertility to male sterile lines. a. What are the crosses male sterile female x FF male? Give the genotypes and phenotypes of the offspring in each cross. Explain.arrow_forwarda. How many generations are presented in this pedigree? b. What are the most probable genotype of III-3, IlI-5, and III-8? c. What is the probability that II- 1 and Il-2 will have another normal offspring? Show punnet square and explain your answer. d. Who among the individuals are affected?arrow_forward
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