CAMPBELL BIOLOGY IN FOCUS (LL)-W/MOD.MA
3rd Edition
ISBN: 9780135686065
Author: Urry
Publisher: PEARSON
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Chapter 9, Problem 11TYU
SYNTHESIZE YOUR KNOWLEDGE
Shown here are two He La cancer cells that are just completing cytokinesis. Explain how the cell division of cancer cells like these is misregulated. What genetic and other changes might have caused these cells to escape normal cell cycle regulation?
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Hi, can you explain this concept: cell cycle progression can be halted at several points by the tumor suppressor gene product p53, activated in response to checkpoints sensing DNA and possibly also chromosome damage; loss of p53 would remove this brake to cycling. How these events can lead to cancer progression?
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Chapter 9 Solutions
CAMPBELL BIOLOGY IN FOCUS (LL)-W/MOD.MA
Ch. 9.1 - How many chromosomes are drawn in each part of...Ch. 9.1 - WHAT IF? A chicken has 78 chromosomes in its...Ch. 9.2 - How many chromosomes are shown in the drawing in...Ch. 9.2 - Compare cytokinesis in animal cells and plant...Ch. 9.2 - Prob. 3CCCh. 9.2 - Compare the roles of tubulin and actin during...Ch. 9.3 - Prob. 1CCCh. 9.3 - Prob. 2CCCh. 9.3 - Compare and contrast a benign tumor and a...Ch. 9.3 - Prob. 4CC
Ch. 9 - Through a microscope, you can see a cell plate...Ch. 9 - In the cells of some organisms, mitosis occurs...Ch. 9 - Which of the following does not occur during...Ch. 9 - Cell A has half as much DNA as cells B, C, and...Ch. 9 - The drug cytochalasin B blocks the function of...Ch. 9 - DRAW IT Draw one eukaryotic chromosome as it would...Ch. 9 - The light micrograph shows dividing cells near the...Ch. 9 - SCIENTIFIC INQUIRY Although both ends of a...Ch. 9 - FOCUS ON EVOLUTION The result of mitosis is that...Ch. 9 - FOCUS ON INFORMATION The continuity of life is...Ch. 9 - SYNTHESIZE YOUR KNOWLEDGE Shown here are two He La...
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- Figure 10.13 Rb and other proteins that negatively regulate the cell cycle are sometimes called tumor suppressors. Why do you think the name tumor suppressor might be appropriate for these proteins?arrow_forwardFigure 28.11 depicts the eukaryotic cell cycle. Many cell types “exitâ€� the cell cycle and don’t divide for prolonged periods, a state termedG0; some, for example neurons, never divide again. a. In what stage of the cell cycle do you suppose a cell might be when it exits the cell cycle and enters G0? b. The cell cycle is controlled by checkpoints, cyclins, and CDKs. Describe how biochemical events involving cyclins and CDKs might control passage of a dividing cell through the cell cycle.arrow_forwardFighting Cancer by Disrupting Mitosis Scientists have identified a number of toxins that disrupt mitosis. These toxins can be used in many different ways – some of them are used during scientific research to arrest the cell cycle at specific points so that the cells can be studied. Others have clinical applications as chemotherapeutic drugs that are useful in the treatment of cancer, as well as other types of disease. Study the list of toxins below, and use the information provided and your understanding of mitosis to answer the questions below. Note: some of these drugs are currently approved for clinical use, while others are still in development. For the purposes of this exercise, assume that all of them are available for use. Drug How it affects mitosis Status of drug Vincristine Prevents polymerization of tubulin Approved Paclitaxel Prevents depolymerization of tubulin and can result in multipolar spindle formation Approved Flavopiridol Blocks Cdk-1. Cdk-1 is a kinase that helps…arrow_forward
- Discuss the complete cell cycle in a human cell, mitosis and meiosis, and the regulatory components (i.e. the proteins associated with cellular checkpoints) of the cell cycle. Tumor growth results when the cell cycle checkpoints are ignored. Give an example of how tumor growth could result from either a loss-of-function or a gain-of-function mutation.arrow_forwardBriefly describe the cell cycle, its checkpoints, and the general proteins required to move past each checkpoint. For each cell cycle checkpoint, be sure to describe what the cell is "checking for" and how this "check" occurs, along with the result if the checkpoint cannot be passed. Your answer should also include a description of the structure of MPF, its regulation, and its general targets or functions. Be sure to include any accessory molecules or proteins involved in regulation of MPF, while also describing the process by which MPF is formed and activated. In this answer, you should also choose two proteins involved in the cell cycle, which, if mutated, will cause cancer. Describe these proteins and their normal functions, and then show how a mutation in these proteins will result in cancer.arrow_forwardShown here are two HeLa cancer cells that are just completing cytokinesis. Explain how the cell division of cancer cellslike these is misregulated. Identify genetic and other changesthat might have caused these cells to escape normal cell cycleregulationarrow_forward
- In your own words, explain how cancer cells differ from normal cells in regard to the following: Molecular controls of the cell cycle (include Cdk and Cdk/cyclin complexes, p53 gene/protein, Rb gene/protein in response)arrow_forwardWhat role do aurora kinase play in the cell cycle and how would using these kinases as target for cancer treated work?arrow_forwardIn experiment of importance of cell cycle control, what does your reults indicate about cell cylce control? suppose a person developed a mutation in a somatic cell diminishes the performance of the body's natural cell cycle control proteins. this mutation resulted in cancer, but was effectively treated with cocktail of cancer-fighting techniques. is it possible for this person's future children to inherit this cancer-causing mutation? Be specific when you are explain why or why not.arrow_forward
- Hi can you elaborate in detail about the following; thanks. The fabrication of 3D printers cellular scaffolds for cancer research. Would this process is viable? Are there potential disadvantages to this model that can be solved by a traditional or other novel method?arrow_forwardBy what molecular pathway does loss of cell cycle regulation in an organism lead to cancer? What genetic changes can cooperate to accomplish the cancer cell’s escape from the normal balance of cell growth?arrow_forwardPart A and B A. What below would be likely to lead to cancer development? A) Overexpression of a cell cycle checkpoint inhibitor B) Loss of expression of a growth factor that promotes cell cycle entry C) Overexpression of a receptor tyrosine kinase that promotes cell cycle entry D) Overexpression of a DNA damage repair enzyme E) Loss of expression of a regulatory transcription factor that activates transcription of a cyclin B. Taxols inhibit the proper function of microtubules and are frequently used as chemotherapy drugs. What is the function of microtubules during the cell cycle? A) They promote the G1 to S checkpoint B) They normally inhibit M phase from being completed C) They form the mitotic spindle E) They mediate DNA replication F) They form the cleavage furrow during cytokinesisarrow_forward
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cell division of meiosis and mitosis; Author: Stated Clearly;https://www.youtube.com/watch?v=A-mFPZLLbHI;License: Standard youtube license