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There are now nearly 200 recognized breeds of dog, from the affenpinscher to the Yorkshire terrier. But several of these suffer from medical problems due to the inbreeding required to establish the breed. For example, nearly every Cavalier King Charles Spaniel (discussed in the Biology and Society section) suffers from heart murmurs caused by a genetically defective heart valve. Such problems are likely to remain as long as the organizations that oversee dog breeding maintain strict pedigree requirements. Some people are suggesting that every breed be allowed to mix with others to help introduce new gene lines free of the congenital defects. Why do you think the governing societies are resistant to such crossbreed mixing? What would you do if you were in charge of addressing the genetic defects that currently plague some breeds?
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Campbell Essential Biology (7th Edition)
- In humans, there is a gene called sickle-cell anemia, which produces severe anemia when homozygous recessive. The name of the disease comes from the fact that many red blood cells take on abnormal sickle shape. People homozygous recessive for this trait usually die before adulthood. Heterozygous people appear normal, but when a sample of the blood is held under low oxygen concentration, the red cells take on the sickle shape. A young woman about to be married is concerned about her future children because her brother died of sickle-cell anemia. A sample of her blood sickles under low oxygen concentration, but that red blood of her perspective husband remains normal. What can you say about the woman and the man, and about their future children? HINT: Use Punnett square to help you and receive full creditarrow_forwardIn humans, there is a gene called sickle-cell anemia, which produces severe anemia when homozygous recessive. The name of the disease comes from the fact that many red blood cells take on abnormal sickle shape. People homozygous recessive for this trait usually die before adulthood. Heterozygous people appear normal, but when a sample of the blood is held under low oxygen concentration, the red cells take on the sickle shape. A young woman about to be married is concerned about her future children because her brother died of sickle-cell anemia. A sample of her blood sickles under low oxygen concentration, but that red blood of her perspective husband remains normal. What can you say about the woman and the man, and about their future children?arrow_forwardSometimes, genetic make-ups do not show up as traits. Let us assume Jane has beautiful brown eyes. Her dad has beautiful blue eyes (pure-bred blue eyes, to say, he has only blue eye genes), while her mom has beautiful brown eyes (pure-bred brown eyes, to say, she has only brown eye genes). Then Jane must be a half brown eye and a half-blue eye, but she has only brown eyes. Why and how this could happen?arrow_forward
- People who like certain purebred dog breeds, such as German shepherd dogs, are often saddened to learn that some individuals of these purebred breeds have specific genetic defects that might be due to single mutations that are present in the breed. For example, German shepherd dogs often suffer from hip dysplasia. Not all German shepherd individuals seem to have this mutant allele for hip dysplasia. 1. How would linkage help select a German shepherd population that has all the phenotypic traits you want with this breed while no longer having a genetic predisposition to hip dysplasia?arrow_forwardDuring the millennia in which selective breeding was practiced, why did breeders fail to uncover the principle that traits are governed by discrete units of inheritance (that is, by genes)?arrow_forwardConsider Mendelian traits versus polygenic traits. What impact do modifications, such as those offered by CRISPR and genetic testing, have on the generational lineage of these traits?Are some traits (e.g., susceptibility to Sickle Cell Anemia) worth removing from our genome? Support your position.arrow_forward
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forward
- Which of the following is not true of the sickle-cell allele? a)it became an important genetic factor after slash-and-burn agriculture was introduced b)it became an important genetic factor after fields were cleared that put humans near mosquitos c)it became an important genetic factor approximately 2000 years ago d)it provides a reproductive advantage to heterozygotes e)only homozygous normals will survive thanks to this traitarrow_forwardThe pedigree shown below depicts crosses performed as part of an antelope captive-breeding program. Use the pedigree information to calculate the coefficient of inbreeding (F) for the mating of IV-12 and III-9 that produces the animal identified as V-13.arrow_forwardMany genetic studies, particularly those of recessive traits, have focused on small, isolated human populations, such as those on islands. Suggest one or more advantages that isolated populations might have for the study of recessive traits.arrow_forward
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning