Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 9, Problem 8TY
Summary Introduction
Introduction: Ligands are important cellular molecules that conduct signals during any cellular activity. Different ligands have different cellular receptors which get activated by their respective ligand and the cellular process is initiated. The absence of the required ligand during a cellular process can prevent the cellular process from completing.
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All cells of a multicellular organism may not respond in the same wayto a particular ligand (signaling molecule) that binds to a cell surfacereceptor. The difference in response may be due toa. the type of receptor for the ligand that the cell expresses.b the affinity of the ligand for the receptor in a given cell type.c. the type of signal transduction pathways that the cell expresses.d. the type of target proteins that the cell expresses.e. all of the above.
A biochemist is designing a new drug that will mimic the shape and function of a particular intercellular signaling molecule. Therefore she must produce a molecule that will bind to the receptor protein and...
A. produce a cellular response by altering the Na+/K+ pump located near the receptor site.
B. induce a change in the receptor molecule shape, which will ultimately prevent a cellular response.
C. induce a change in the receptor molecule shape, which will ultimately produce a cellular response.
D. induce a change in the phospholipid bilayer that causes a polar reversal allowing the molecules to be endocytose (engulfed).
For cellular transduction, why is it useful that phosphorylation cascades have a series of protein kinases?
a.
they amplify the original signal
b.
they always lead to the same cellular response
c.
the number of molecules used is small and fixed
d.
they are cell specific
Chapter 9 Solutions
Biology
Ch. 9.1 - Figure 9.1 Response of a yeast cell to glucose....Ch. 9.1 - Prob. 1CSCh. 9.1 - Which type of signal, paracrine or endocrine, is...Ch. 9.1 - Prob. 3CCCh. 9.2 - Prob. 1CSCh. 9.2 - Prob. 2CSCh. 9.2 - Prob. 1CCCh. 9.3 - Prob. 1CSCh. 9.3 - Prob. 1CCCh. 9.3 - Prob. 2CC
Ch. 9.3 - In the case of signaling pathways involving...Ch. 9.5 - Prob. 1EQCh. 9.5 - Prob. 2EQCh. 9.5 - Prob. 3EQCh. 9.5 - Prob. 1CCCh. 9 - Prob. 1TYCh. 9 - Prob. 2TYCh. 9 - Prob. 3TYCh. 9 - Prob. 4TYCh. 9 - Prob. 5TYCh. 9 - The relay protein Ras is part of the EGF pathway...Ch. 9 - Prob. 7TYCh. 9 - Prob. 8TYCh. 9 - Prob. 9TYCh. 9 - Prob. 10TYCh. 9 - Prob. 1CQCh. 9 - Conceptual Questions What are the three stages of...Ch. 9 - Prob. 3CQCh. 9 - Prob. 1COQCh. 9 - Prob. 2COQ
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- Scaffold proteins (a) release kinases and phosphatases into the extracellular fluid (b) bind G proteins to cell membranes (c) increase accuracy but slow signaling cascades (d) organize groups of intracellular signaling molecules into signaling complexes (e) are transcription factors found mainly in plant cellsarrow_forwardDuring cell signaling, binding of a ligand to the outside of a cell leads to: A. A signal being sent inside the cell B. The ligand being transported into the cell C. A and B D. None of the abovearrow_forwardYou stimulated the cell with a ligand and analyzed the response. Upon ligand treatment, the cell increased the expression of gene α and decreased expression of gene β. When you inhibit cyclic AMP production by treating the cell with an inhibitor of Adenylyl cyclase, the increased expression of gene α was not observed but the decrease gene β expression was still observed. a) What you can expect for gene α regulation by this ligand? What signaling mechanism could be used? b) To determine how gene β is regulated by the ligand via what signaling mechanism, provide your hypothesis and indicate a potential experiment that you can perform to test that.arrow_forward
- A researcher tested Compound A on chemotaxing cells and measured the relative amount of filamentous actin found in the cells at different times. Based on the researcher’s observations on filamentous actin, what other observation regarding cell chemotaxis was MOST likely observed? A. The cell moved toward the source of the signaling molecule only after the addition of Compound A. B. The cell moved away from the source of the signaling molecule only after the addition of Compound A. C. The cell first moved toward and then away from the signaling molecule after the addition of Compound A. D. The cell did not move toward or away from the signaling molecule after the addition of Compound A.arrow_forwardDraw a cell. Draw a receptor that binds to a signaling molecule on the outside of the cell and a receptor that binds to a signaling molecule on the inside of the cell. What property does a signaling molecule that crosses the cell membrane (plasma membrane) need?arrow_forwardWhich of the following are methods of cellular signaling? Select one: a. All the answers are correct. b. Connections through fibers of the ECM from one cell to another c. Ligand binding to a receptor in the cell membrane d. Desmosomes ‘pulling’ one cell to another e. Lipid or gas ligand binding to an intracellular receptorarrow_forward
- compare and contrast how GPCRs and RTKs transduce their signal to the cell? include the types of ligands they bind, the GTP binding protein that is activated, and how the signal is transduced and amplified. what effects does it have on the cell?arrow_forwardIn intercellular signaling pathways, some receptor proteins can also act as a transcription factor (changing gene expression), because these receptors are ________. A) Group of answer choices B) Intracellular receptors C) Membrane bound receptors D) G protein coupled receptors E) Enzyme linked receptors F) Fast ligand-gated ion channelsarrow_forwarda universal feature of cell signaling receptors is that they? a. undergo a structural (shape) change when the signal molecule is bound b. are present only in the plasma membrane c. are only ion channels d. are protein kinases e. aer only nuclear receptorsarrow_forward
- G proteins are involved wheneverA. Binding of messenger molecules to cell surface receptors triggers a target cell response.B. Binding of ligand molecules to cell surface receptors triggers activation or inhibition of enzymes,C. Binding of ligand molecules to cell surface receptors triggers synthesis of second messengers,D. Binding of ligand molecules to cell surface receptors triggers a change.E. All of the above.arrow_forwardYou are interested in monitoring the movement of a protein kinase called PKB from the cytoplasm to the nucleus during a signaling pathway that is active in brain cells. If you wanted to monitor the changes in the subcellular location of PKB, describe one way you could do that and explain why you think it would provide insights into how PKB changes its subcellular location.arrow_forwardPlease choose one of these choices A. Since protein A is embedded in the membrane., the mutation will be silent and not affect the cellular response. B. The molecule that normally binds to protein A will not enter the cell, thus no cellular response will occur. C. The molecule that normally binds to protein A will no longer attach, deactivating the cellular response. D. Production if activated molecule 1 will stop, bht production of activated molecules 2 and 3 will continue.arrow_forward
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