Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 9, Problem 4TY
Summary Introduction
Introduction: The ligand, which is a signaling molecule, shows high degree of specificity towards its receptor. The binding between ligand and receptor occurs when they collide in the correct orientation and form ligand-receptor complex.
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Students have asked these similar questions
1) How many binding sites per molecule does the receptor have?
2) What type of cooperativity is observed with this binding protein?
a) No cooperativety
b) Positive homotropic cooperativity
c) Positive heterotropic cooperativity
d) Negative homotropic cooperativity
e) Negative heterotropic cooperativity
f) none of the above
Explain whether the specificity of interaction will be high or low for each given situation.
a. The value of KD of the ligand's interaction to the target receptor is very much lower than the value of KD of the ligand's interaction to off-targets.
b. The ligand concentration [L] is higher than the KD value of its interaction with the target and the KD value of its interaction to off-targets.
A ligand binds to the extracellular portion of a receptor. Another ligand binds to an identical half of the same receptor. When this happens, the two halves come together and the intracellular portion adds phosphates from ATP to tyrosine amino acids it the receptor structure. This passage describes what kind of receptor?
Select one:
a. A G-protein coupled receptor
b. A receptor tyrosine kinase
c. A receptor tyrosine phosphatase
d. A ligand-gated kinase channel
Chapter 9 Solutions
Biology
Ch. 9.1 - Figure 9.1 Response of a yeast cell to glucose....Ch. 9.1 - Prob. 1CSCh. 9.1 - Which type of signal, paracrine or endocrine, is...Ch. 9.1 - Prob. 3CCCh. 9.2 - Prob. 1CSCh. 9.2 - Prob. 2CSCh. 9.2 - Prob. 1CCCh. 9.3 - Prob. 1CSCh. 9.3 - Prob. 1CCCh. 9.3 - Prob. 2CC
Ch. 9.3 - In the case of signaling pathways involving...Ch. 9.5 - Prob. 1EQCh. 9.5 - Prob. 2EQCh. 9.5 - Prob. 3EQCh. 9.5 - Prob. 1CCCh. 9 - Prob. 1TYCh. 9 - Prob. 2TYCh. 9 - Prob. 3TYCh. 9 - Prob. 4TYCh. 9 - Prob. 5TYCh. 9 - The relay protein Ras is part of the EGF pathway...Ch. 9 - Prob. 7TYCh. 9 - Prob. 8TYCh. 9 - Prob. 9TYCh. 9 - Prob. 10TYCh. 9 - Prob. 1CQCh. 9 - Conceptual Questions What are the three stages of...Ch. 9 - Prob. 3CQCh. 9 - Prob. 1COQCh. 9 - Prob. 2COQ
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- A biochemist is designing a new drug that will mimic the shape and function of a particular intercellular signaling molecule. Therefore she must produce a molecule that will bind to the receptor protein and... A. produce a cellular response by altering the Na+/K+ pump located near the receptor site. B. induce a change in the receptor molecule shape, which will ultimately prevent a cellular response. C. induce a change in the receptor molecule shape, which will ultimately produce a cellular response. D. induce a change in the phospholipid bilayer that causes a polar reversal allowing the molecules to be endocytose (engulfed).arrow_forwardwhen a chemical messenger (or ligand) reaches a target cell, it binds to a receptor. A hydrophobic ligand binds to a(n) _______, whereas a hydrophilic ligand binds to a(n)_________. a. agonist receptor; antagonic receptor b. transmembrane receptor; intracellular receptor c. antagonist receptor; agonist receptor d. intracellular receptor; transmembrane receptorarrow_forwardAvidin (egg white) protein binds with biotin ligand with Kd = 1 X 10 -15 M whereas calmodulin is a protein that binds to Ca+2 ions has Kd = 1 X 10 -6 M a.) Interpret the data regarding an attraction between a protein and its ligand based on the Kd values for two proteins? If somebody is allergic to egg white. Do you think eating biotin would be a good idea?arrow_forward
- You can choose one or more than one option The dissociation constant (Kd) of a receptor is: BIOCHEMISTRY basic the concentration of a ligand that produces 100% occupancy of the receptor the concentration of a ligand that produces 50% of the maximal effect. the measurement of specificity between ligand and its receptor. the measurement of speed by which a ligand will dissociate from its receptor. the measurement of affinity between a ligand and its receptor and the inverse of the association constant. During an experiment with Drosophila, it was discovered that all females had red eyes. unlike males. A conclusion based on this observation would be: MOLECULAR BIOLOGY basic The gene for eye color is located on the X chromosome. The females are homozygotes The gene for eye color is dominant. The eye color results from multigenic linkage. The eye color phenotype is sex-linked A secondary lysosome: CELL BIOLOGY advanced a lysosome that provides a backup to the primary…arrow_forwardDopamine, epinephrine (or norepinephrine) and histamine are important neurotransmitter agonists. When these ligands interact with their cellular receptors, how do they mainly elicit their responses? Choose the correct answer(s) and explain why. a) Activate adenylyl cyclase directly, leading to increased intracellular cAMP levels b) Activate phospholipase C c)Induce or inhibit synthesis of ligand specific intracellular proteins d) Open or close ligand gated ion channels e) Regulate intracellular second messengers through G-protein-coupled receptorsarrow_forwardThe drug Buckeyium binds to the NMDA receptor at the orthosteric binding site (were glutamate would normally bind). Assume that glycine is already bound, and that magnesium is not blocking the NMDAR ion channel. If the channel does not open as a result of Buckeyium binding than Buckeyium would be considered a ____________. A. Indirect Antagonist B. Positive Allosteric Modulator C. Negative Allosteric Modulator D. None of the choice options are correct E. Non-Competitive Antagonistarrow_forward
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