BIOLOGY CONNECT ACCESS CARD 1-SEMESTER
12th Edition
ISBN: 9781264019090
Author: Raven
Publisher: MCG/CREATE
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Chapter 9.4, Problem 4LO
Summary Introduction
To determine: The possible reasons for the mutation of Ras protein in human cancers.
Introduction: Ras is a GTP binding protein and acts as a link between receptor tyrosine kinase (RTK) and mitogen-activated protein (MAP) kinases. The protein is in an active state when bound to GTP and is in an inactive state when bound to GDP.
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Chapter 9 Solutions
BIOLOGY CONNECT ACCESS CARD 1-SEMESTER
Ch. 9.1 - Prob. 1LOCh. 9.1 - Prob. 2LOCh. 9.2 - Prob. 1LOCh. 9.3 - Prob. 1LOCh. 9.3 - Prob. 2LOCh. 9.4 - Prob. 1LOCh. 9.4 - Describe how information crosses the membrane in...Ch. 9.4 - Prob. 3LOCh. 9.4 - Prob. 4LOCh. 9.5 - Prob. 1LO
Ch. 9.5 - Prob. 2LOCh. 9 - Paracrine signaling is characterized by ligands...Ch. 9 - Signal transduction pathways a. are necessary for...Ch. 9 - The function of a ____is to add phosphates to...Ch. 9 - Which of the following receptor types is NOT a...Ch. 9 - How does the function of an intracellular receptor...Ch. 9 - Signaling through receptor tyrosine kinases often...Ch. 9 - Prob. 7UCh. 9 - Which of the following best describes the...Ch. 9 - Prob. 1ACh. 9 - The ion Ca2+ can act as a second messenger because...Ch. 9 - Different receptors can have the same effect on a...Ch. 9 - In comparing small G proteins like Ras and GPCR...Ch. 9 - Prob. 5ACh. 9 - The receptors for steroid hormones and peptide...Ch. 9 - Describe the common features found in all examples...Ch. 9 - The sheet of cells that form the gut epithelium...
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- What is the function of RAG1? What will happen if RAG1's function is lost due to mutations?arrow_forwardIt seems that the expert only addressed the background of prorooncogen and the impact of Ras causing various mutations and affecting several codons of the genes, but didn't address the problem "Why would a translocation that put Ras behind the promoter region of the actin gene lead to the formation of an oncogene?"arrow_forward''The chemical carcinogen dimethylbenz[a]anthra-cene (DMBA) must be an extraordinarily specific mutagensince 90% of the skin tumors it causes have an A-to-T alter-ation at exactly the same site in the mutant Ras gene.'' Is this statement true? Explain why or why not.arrow_forward
- Mutations that inactivate p53 have a recessive phenotype, whereas mutations affecting Ras are dominant. Explain the difference.arrow_forwardIs the presence of oncogenic Ras necessary for transient inflammatory stimulation to induce chronic pathologies (such as cancer) OR is chronic inflammation essential for oncogenic Ras to induce tumorigenesis?arrow_forwardDo you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras that lead to cancer? Please explain.arrow_forward
- Describe the common signal transduction event that is perturbed by cancer-promoting mutations in the genes encoding RAS and NF-1. Why are mutations in RAS more commonly found in cancers than mutations in NF-1?arrow_forwardHow does constitutively active Ras promote cancer?arrow_forwardWhat is claudin16 genearrow_forward
- Compare and contrast the regulation of Ras with trimeric G proteins.arrow_forwardHemophilia in the royal family was caused by the presence of a mutation in the gene for factor IX that altered the splicing of the exons and created a new stop signal in the mRNA for factor IX. Explain how a splicing mutation could produce a premature stop signal.arrow_forwardDescribe how mutations in genome maintenance factors promote tumorigenesis. Why would inactivation of a mis- match repair gene cause colon cancer?arrow_forward
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