EBK ESSENTIALS OF GENETICS
9th Edition
ISBN: 9780134190068
Author: Palladino
Publisher: YUZU
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Chapter CHST1, Problem 1DQ
Imprinting disorders do not involve changes in DNA sequence, but only the methylated state of the DNA, or the modification of histones. Does it seem likely that imprinting disorders could be treated prenatally or prevented by controlling the maternal environment in some way, perhaps by dietary changes?
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Chapter CHST1 Solutions
EBK ESSENTIALS OF GENETICS
Ch. CHST1 - What are the major mechanisms of epigenetic genome...Ch. CHST1 -
2. What parts of the genome are reversibly...Ch. CHST1 - What are the roles of proteins in histone...Ch. CHST1 - Describe how reversible chemical changes to...Ch. CHST1 -
5. What is the histone code?
Ch. CHST1 - Prob. 6RQCh. CHST1 - Why are changes in nucleosome spacing important in...Ch. CHST1 -
8. How do microRNAs regulate epigenetic...Ch. CHST1 - What is the role of imprinting in human genetic...Ch. CHST1 - Imprinting disorders do not involve changes in DNA...
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- Theodor Boveri predicted that malignancies would often be associated with chromosomal mutation. What lines of evidence substantiate this prediction?arrow_forwardSpecific environmental or nongenetic factors can cause epigenetic modifications. Identical twins have essentially the same DNA sequences; however, aging and significant lifestyle differences cause changes in _____ because: Genomic imprinting Histone modification Chromatin structure DNA methylationarrow_forwardWhat type of epigenetic change is responsible for genomic imprinting?arrow_forward
- Phenotypes can be controlled by many processes besides the actual genotype present. Explain one example of epigenetics that can control phenotype expressionarrow_forwardMany oncogenes result from mutations that cause excessive expression of a protein in cells where it is normally not expressed or is expressed at inappropriate times during development. This type of mutation can be described as ________. A) amorphic B) hypomorphic C)hypermorphic D) neomorphic E) dominant negativearrow_forwardDefine the term maternal effect genes, and explain why the protein products of some of these genes are called morphogens.arrow_forward
- Explain the unique features of Ig genes.arrow_forwardPlease explain how the deletion of the same set of genes can result in such different diseases. The example for this question being Prader-willi syndrom and Angelman syndrome. In your answer, be sure to discuss the role of genetic imprinting and epigenetics.arrow_forwardYou found a strain of mutant fruit flies (Drosophila) living on the rotten bananas in your dorm room. You notice that many of the larvae have abnormal abdominal segments. You want to know if the “abdomenless” mutation is a maternal effect gene. Describe an experiment you would do to determine this, and the results that would support and contradict the notion that the abdomenless gene encodes a maternal determinant.arrow_forward
- In humans, dosage compensation is accomplished by: inactivating one X chromosome in female somatic cells inactivating one homolog from each homologous pair of chromosomes in female somatic cells inactivating the Y chromosome in male somatic cells increasing gene expression from the X chromosome in male somatic cellarrow_forwardIn humans, hemophilia is an X-linked recessive gene and will only be expressed in females if they are homozygous for this gene. However, in some rare cases, a heterozygote becomes hemophilic. Explain thoroughly how this happened.arrow_forwardFor the Igf2 gene, where do de novo methylation and maintenancemethylation occur?a. De novo methylation occurs in sperm, and maintenancemethylation occurs in egg cells.b. De novo methylation occurs in egg cells, and maintenancemethylation occurs in sperm cells.c. De novo methylation occurs in sperm, and maintenancemethylation occurs in somatic cells of offspring.d. De novo methylation occurs in egg cells, and maintenancemethylation occurs in somatic cells of offspring.arrow_forward
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