EBK ESSENTIALS OF GENETICS
9th Edition
ISBN: 9780134190068
Author: Palladino
Publisher: YUZU
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Question
Chapter CHST4, Problem 8RQ
Summary Introduction
To review:
The relationship between CYP2D6 variants and the response of patients to the breast cancer drug, tamoxifen using PharmGKB database.
Introduction:
An individual’s genomic makeup reveals the response of the body to a particular drug, this study is known as Pharmacogenomics. The genes encode various enzymes and proteins known to metabolize the drug, hence the rate of
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Why is there caution against prescribing imatinib with strong CYP3A4 inhibitors?
Based on data, which aptamer would consider to be the primary receptor for the FGF5 ligand? Explain your answer.
According to the research article: “Telomerase Modulates Wnt Signalling by Association with Target Gene Chromatin,” how did the authors determine that TERT, Brg1, and beta catenin were all part of the same protein complex on TCF sites in vivo? Describe the assay used to determine this.
Chapter CHST4 Solutions
EBK ESSENTIALS OF GENETICS
Ch. CHST4 - What is pharmacogenomics, and how does it differ...Ch. CHST4 - Describe how the drug Herceptin works. What types...Ch. CHST4 - Prob. 3RQCh. CHST4 - Prob. 4RQCh. CHST4 - What types of genetic tests are currently...Ch. CHST4 - Give two examples of how genomic studies have...Ch. CHST4 - Why is it necessary to examine gene-expression...Ch. CHST4 - Prob. 8RQCh. CHST4 - In this chapter, we present three case studies...Ch. CHST4 - What are the biggest challenges that must be...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor biology, what is the mutator phenotype hypothesis? What are some ways in which error-prone polymerases could be targeted for potential anti-cancer treatments?arrow_forwardDiscuss the advantages and disadvantages of general chemotherapy like Etoposide compared to specific inhibition of EGFR.arrow_forwardHow do loss of function mutations associated with Artemis (protein) cause their resulting phenotypes? Explain how genetically modified HSCs can treat these phenotypes.arrow_forward
- a.What would happen if IKKbeta did not phosphorylate IkappaB? b.Why is it so hard to make cytokine therapies? c.Why would you use the MyD88 independent pathway versus the MyD88 dependent pathway?arrow_forwardPls do not copy paste Explain, the mechanism of chaperone mediated autophagy.arrow_forwardexplain how a wild type PAH enzyme works to process phenylalanine and how a mutated PAH enzyme could lead to PKU.arrow_forward
- Propose a strategy to prevent HIF-alpha signaling in the TME. What do you think would happen in a transgenic mouse with a total knockout of HIF-alpha?arrow_forwardName two ways in which loss of p53 function contributes to a malignant phenotype. Explain how benzo(a) pyrene can cause loss of p53 function. Hint: Loss of p53 function occurs in the majority of human tumors.arrow_forwardDescribe the mutational event that produces the MYC oncogene in Burkitt’s lymphoma. Why does the particular mechanism for generating oncogenic MYC result in a lymphoma rather than another type of cancer? Describe another mechanism for generating oncogenic MYC.arrow_forward
- X31b is an experimental compound that is taken up by rapidly dividing cells. Research has shown that X31b stimulates the methylation of DNA. Some cancer researchers are interested in testing X31b as a possible drug for treating prostate cancer. Offer a possible explanation for why X31b might be an effective anticancer drug.arrow_forwardExplain the mechanism of Warburg effect and how it benefits cancer cells? With this guidearrow_forwardRNAi is currently being tested as a therapeutic tool for genetic diseases and other conditions. Consider the following: cystic fibrosis caused by loss of function of the CFTR gene, HIV infection, and cancer caused by hyperactivity of a growth factor receptor. Which of these may be treatable by RNAi, and which not? Explain your reasoning.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
What is cancer? What causes cancer and how is it treated? *UPDATE*; Author: Cancer Treatment Centers of America - CTCA;https://www.youtube.com/watch?v=_N1Sk3aiSCE;License: Standard Youtube License