DNA-binding domain

A sodium channel consists of four homologous domains with each domain containing six alpha helix transmembrane segments. The two beta segments can be used for stability, selectivity or other processes dependent on the type of channel. Each segment is labeled s1-s6 with s4 as the voltage sensor composed of

Prostate cancer originates in the secretory epithelial compartment of the prostate. The major function of these cells is to secrete protein components of prostatic fluid such as MSMB. With progression to metastasis, cells proliferate faster and lose their differentiated secretory phenotype. Expression of the mRNA of tumor suppressors and many cytoskeletal proteins decline. On the other hand, expression of genes associated with cell cycle [cyclins and cyclin dependent kinases] and protection from

level of DNA supercoiling, an important property of DNA and chromatin (Gilbert and Allan, 2014). The supercoiling level is modified by a reaction that consists in the transient breakage of the DNA phosphodiester bonds and the movement of strands across the transient breaks (Tse-Dinh and Wang, 1986). In prokaryotes, these enzymes can be classified into two major groups, according to the mechanism of action. While the topoisomerase II (DNA gyrase) generates negative supercoils into relaxed DNA and relax

transporters vary between eukaryote and prokaryote organisms, ABC protein shows highly conservative amino acid domains within NBDs. However, NBD have three well studies motifs; ATP-binding sequences for the phosphate-binding loop (P-loop or Walker A motif), walker B boxes, and ABC signature, ex (LIVMYA), which is fix in between Walker boxes (Akifumi Sugiyama, et al, 2006) Plant ABC transporters uses different nomenclatures to shape plant ABC subfamilies, a consistent nomenclature with Human Genome

JCV belongs to the Polyomaviridae family comprising non-enveloped tumor viruses with icosahedral capsids containing small, circular, double-stranded DNA genomes [White et al., 2005]; it encloses a large number of members that are able to infect various animal species including rodents, rabbits, birds and primates, including man [Imperiale, 2001; Delbue et al., 2012]; in particular, to date, have been discovered 11 polyomaviruses infecting man [White et al., 2013; Feltkamp et al., 2013] (Fig. 1.1)

factors of H pyroli are responsible for this cell cycle alteration; few of them are described below. Cag Pathogenecity Island Cag PAI (cag pathogenecity island) is a 40kbp region of DNA in the genome of H pyroli encoding a number of virulence factor. Cag PAI has different GC content than the flanking genomic DNA indicating cag PAI to be a horizontally transferred entity. Cag PAI encodes components of T4SS that binds to B integrin and is indispensible for delivering Cag A proteins into the host

1  Study Guide for Lectures 8/24, 8/26, 8/31, and 9/2 Note: It is highly suggested that you reference the figures/figure legends shown in class to further help you understand class material. The Genome Project (~92% complete): • 20,000-28,000 genes in the human genome o The genome was found using a shotgun sequence. o 10% of the genome is Long Intersperse Nuclear Elements (=LINEs). This leaves the questions as to which part of the genome are LINEs?  80,000-120,000 proteins in a cell.  200,000-2

Dr Sleeman – “From DNA to secreted protein: describe the key molecular events required and their organisation within the cell” The genome, all the genetic material encoded within the sequence of deoxyribonucleic acid (DNA), which is unique to each individual organism, has all the information required for a cell to sustain life. This is possible due to gene expression which is the process of the genetic code, DNA, being translated into proteins which a cell can then utilise for specific functions

--- as an effect, the inhibitory protein (IP) uncouples from the death domain located within the cell (Wajant and Pfizenmaier, 2003). The uncoupling of the IP creates an opportunity for a signal transducing adapter protein known as, “TNFR-type 1-associated Death domain protein” (TRADD), to react with the death domain and act as a location for consecutive binding of proteins. Ensuing the reaction between TRADD and the death domain, several new reactions can

Caucasians with Northern European heritage (Oates and AMOS, 1994). Starting with a molecular or cellular point of view, Since cystic fibrosis is a genetic disease, where is the cystic fibrosis gene? Cystic fibrosis gene is a 250-kb sequence of genomic DNA located on the long arm of chromosome