Myelin

typically is diagnosed in the second or third decade of life. Normally, nerves are enclosed in myelin sheaths that help facilitate transmission of nerve impulses within the CNS and the peripheral nervous system throughout the body. In patients with MS, the myelin sheath is damaged and eventually degenerates, causing patches of scar tissue called plaques or lesions to occur anywhere randomly on the myelin sheath (Ruto, 2013). This results in impaired nerve conductivity, which interferes with message

experiments best because 1) it mimics the in vivo environment with the presence of all major CNS cell types, 2) myelination has been observed in the model by other investigators, thus fulfill the needs of studying effect of HIV/Tat on both OLs and myelin, and 3) the hBrnAgg model can be maintained for a long period of time (up to 60 days), made it a good model to study long-term effect of HIV/Tat. Our immunostaining experiments suggested that there are far less OLs in the aggregates than we expected

Multiple Sclerosis (MS) is an autoimmune demyelinating disorder it is characterized by inflammation and destruction of CNS myelin. It affects approximately 350,000 persons in the united states and more than 1 million worldwide (Porth,2014). The age of onset is typically between 18 and 45 years of age. Women are affected twice more frequently than men. Etiology is the cause or set of causes of a disease or condition. The cause of MS is unknown but it is likely that multiple factors are a cause for

autoimmune, and degenerative disease of the central nervous system. Its etiology is unknown, but a combination of environmental and genetic factors is likely responsible for its development. MS occurs when one’s immune system attacks the fatty protein myelin, which insulates and protects the axons of oligodendrocytes in the brain and spinal cord. Damage to this sheath can cause the miscommunication between these oligodendrocytes and the rest of the body, and additionally causes painful and debilitating

Multiple sclerosis, or MS, is a very common disease that affects more women than men; at a minimum two to three times relevant in women (Harbo, 2013). Sadly, according to the National Multiple Sclerosis Society, since 1975, there has not been a successful national study of the prevalence in the United States. In order to improve reporting MS, the National MS Society established a method of testing administrative databases. In turn, the Society reported that MS organization have estimated 2.3 million

autoimmune disease in which the surrounding protective coating layer of the axon, myelin, is degraded, resulting in the formation of inflamed lesions (also referred to as plaques) around the regions of the brain and spinal cord. The myelin sheath is not only a protective layer, but it also increases the speed of electrical impulses transfer across the body via saltatory conduction. Depending on the severity of damage to the myelin, it can slow down or distort messages travelling along nerve fibres, some

What Everyone Should Know About Multiple Sclerosis Multiple sclerosis is considered a nervous system disease that affects the brain and spinal cord. The disease remains a mystery to this day since there are no known specific causes. It can be seen that multiple sclerosis is more prevalent in women than in men between the ages of 20-40 (Bethesda 2015). While the disease is typically mild in most cases, some severe cases may result in the loss in the ability to speak, walk, and write. Common symptoms

Multiple sclerosis (MS) is a degenerative and potentially debilitating disorder that affects the spinal cord and brain, collectively known as the central nervous system. Multiple sclerosis evolves gradually throughout time and is considered to be auto-immune, which means the immune system mistakenly attacks healthy cells and tissues that are supposed to be within the body. According to Medscape, symptoms consist of, but are not limited to, sexual problems, ataxia (the inability to control certain

200 new cases of MS are discovered weekly (Pietrangelo, Anne and Higuera, Valencia) . In a healthy person, an insulation covering called myelin, coats the nerve fibers in the CNS (Article from mom). When one develops MS, the communication between their brain and other parts of his/her body is disrupted as “an abnormal immune-mediated response” attacks the myelin coating that encloses nerve fibers in the CNS. This causes a disturbance in communication between the CNS and

functions of the mind and body such as thoughts and body movement. In MS the body's immune system destroys the Myelin Sheath and the nerve fibers. The Myelin Sheath is the protecting cover that surrounded by the nerve fibers. If the Myelin Sheath or nerve fibers are damaged then the nerve impulses in the central nervous system are compromised. Demyelination is the damaging of the Myelin Sheath, afterward a plaque, which is a hardened patch of tissue, forms over the harmed area. This disruption of