1 Specify the role each of the following amino acids play within the crystal structure and/or active site for Be as specific as possible, with pictures (and mechanistic arrows) as necessary. His11 Arg140 Glu89 Trp68
Q: Cellulose cannot be digested and thus does not contribute to the caloric intake in humans. A) True…
A: Cellulose is an intricate organic compound found in large quantities in nature. It is a polymeric…
Q: What is the diffusion coefficient of a membrane-bound protein of molar mass 79,300 daltons density…
A: Diffusion coefficient of the protein is measured as protein mass transfer with between the two…
Q: How consuming too much dietary fat and drinking carbonated drinks affects lipid metabolism
A: Dietary fat and carbonated drink consumption have been found to be associated with several different…
Q: Long explanations are not needed. True or False a. One NADH is produced for every pyruvate…
A: The pentose phosphate pathway is an alternative pathway for glucose oxidation. It provides NADPH for…
Q: Q1. Many of the components for lipid synthesis need to be "activated", which happens by a variety of…
A: Lipids are non-polar biomolecules, which act as the major components of the plasma membrane, energy…
Q: product of the reaction:
A: Lipids are biological molecules that are insoluble in water but soluble in non-polar…
Q: 1. Name and draw diagrammatically the series of mitochondrial electron transfer catalysts, starting…
A: Since you have posted multiple questions we will answer the first question for you. If you want the…
Q: Chemistry A poison has been found to severely compromise the energy production in its victims.…
A: Energy is produced in the mitochondrial matrix through the process of oxidative phosphorylation.…
Q: Genskap/Property A-DNA B-DNA Z-DNA Algehele proporsies/Overall Kort en 1.3.1 Verleng en proportions…
A: The Watson-Crick double-helical model explains the features of the B form of the DNA. There are many…
Q: _____ 1. is the classification of enzyme where carbonic anhydrase belong ______ 2. is the name of…
A: The reaction catalyzed by carbonic anhydrase is given below. H2O + CO2⇌ H2CO3 ⇌ HCO3- + H+. The…
Q: Q2. How many ATPs are lost in the oxidation of this fatty acid because it is poly- unsaturated? In…
A: First lets calculated total ATP yield if this 18C fatty acid (FA) was completely saturated. 2 ATP…
Q: The synthesis of phosphocreatine is unfavorable. If dur- ing extended periods of rest, e.g.,…
A: Phosphocreatine (PCr) - It is a phosphorylated creatine molecule that works as transferable reserve…
Q: Whatarethewater-solublevitamins?Describeeachandtheirsources.
A: Introduction: Vitamins are organic compounds required in the diet in minimal amounts to perform a…
Q: Which is NOT a difference between RNA and DNA? Select one: A. RNA contains uracil; DNA usually…
A: Introduction: Nucleic acids are molecules that store hereditary information for cellular growth and…
Q: What cofactor is formed when this reaction proceeds right during glycolysis? OPO,CH O OH 2-OPO,CH,…
A: Glycolysis is classified as one of the cytoplasmic pathways. The main role of this pathway is to…
Q: Which of the following describes the correct order of energy conversions necessary to form…
A: Bioenergy is described as one of the most crucial resources that are available in order to meet the…
Q: Is it true that coconut oils contain no cholesterol? Provide reasons
A: Coconut oil is basically a tropical oil derived from the dried nuts of coconut palm tree.
Q: Please describe the protein purification process with the aim of purifying a protein which locates…
A: We will answer the first question since the exact one was not specified. Please submit a new…
Q: lease help me answer questions 71 & 77 71. Which of the following are examples of kinetic energy? A.…
A: Introduction: Kinetic energy: The term energy is the ability to do work or cause change. There are…
Q: The two main goals of the citric acid cycle are: (a) citrate synthesis and gluconeogenesis…
A: The citric acid cycle was discovered by H. A. Kreb. The reactions of the citric acid cycle occur in…
Q: depletion of NAD+
A: Nicotinamide adenine dinucleotide ( NAD) is a coenzyme central to metabolism. It is found in all…
Q: malate dehydrogenase is interconverted into isozymic forms by oxidizing and reducing agents
A: Malate dehydrogenase is found in a variety of organs in vertebrates. It has been discovered that…
Q: If OAT takes ornithine and alpha-ketoglutarate as (a) substrates, draw the structures of the…
A: Aminotransferases are group of enzymes that catalyzes the transamination reaction between amino acid…
Q: What are the respective associated substances & processes? reduction regeneration RuBP RUBISCO NADPH…
A: Photosynthesis occurs in basically two steps and they are light reaction and dark reaction. In the…
Q: Failure of anti-oxidant function results in the hydroxylation of an aromatic acid of Enzyme Z and…
A: Sanger DNA sequencing is carried out using ddCCTP for the chain termination. The given peptide is…
Q: pls solve this problem with in 15 to 30 min
A: 1 Hemiacetal in general , when aldehyde can react with alcohol forms hemiacetal. The linear…
Q: Removal of phosphoryl groups is catalyzed by ___________ a. Diphteria toxin and cholera toxin b.…
A: The phosphoryl-transfer potential (the standard energy of hydrolysis) compares the proclivity of…
Q: Is the claim "Our product contains no cholesterol" in coconut oils true? Why or why not?
A: Oils is a commonly usable chemical for various uses.Oil is nonpolar chemical substance which is…
Q: Dicuss two steps involved in pentose phosphate pathway.
A: The pentose phosphate pathway is a metabolic system that runs in the opposite direction of…
Q: 5 Write equilibrium expressions for these reactions. (a) 2H,0,(g)=2H,0(g) + O,g) (b) 2N,0,(g)=…
A: Introduction: A number that relates the concentrations of the beginning compound and products of a…
Q: ACTIVITY 6.2.7 Describe the common structural features and differences for each pair 1. Cellulose…
A: Glucose is referred as one of the most important sugar and this sugar is also present in blood. It…
Q: ACTIVITY 6.2.6 Give the complete name of the disaccharides below: 1. Lactose 2. Cellobiose
A: Essentially, a disaccharide is made up of two monosaccharides (simple sugars) linked together. A…
Q: D-Galactose.
A: ''Since you have asked multiple question, we will solve the first question for you. If you want any…
Q: The synthesis of phosphocreatine is unfavorable. If dur- ng extended periods of rest, e.g., sleeping…
A: Phosphocreatine (PCr) - It is a phosphorylated creatine molecule that works as transferable reserve…
Q: Why are vascular tissues important?
A: The vascular tissue system is made up of a number of vascular bundles that are found throughout the…
Q: Problem 2. Competitive inhibitors are commonly used to make pharmaceuticals. Some cancer drugs act…
A: We need to plot the Lineweaver Burk Plot (LB Plot) to solve this problem. So first we need to find…
Q: Name at least three substrates for the hexokinase enzyme. Why are humans considered…
A: Part 8. The three substrates for hexokinase enzymes are: glucose-6-phosphate dehydrogenase…
Q: What is the difference between substrate-level phosphorylation and oxidative phosphorylation? Please…
A: Phosphorylation : The transfer of the phosphate group from one compound to the other. Substrate…
Q: Describe the effects of (1) oligomycin and (2) uncouplers of oxidative phosphorylation, e.g.,…
A: There are four electron transport chain complexes present in the inner mitochondrial membrane. These…
Q: С 17 Based on the knowledge you gained from the cloning module, which of the bands in the figure is…
A: Agarose gel electrophoresis is a method used in molecular biology to resolve DNA fragments on the…
Q: Show a chemical reaction involving hydrogen peroxide and the enzyme present in potato. What enzyme…
A: Chemical reactions and processes are sped up by catalysts or chemicals found in all living things.…
Q: The phosphorylation of proteins is an important regulatory mechanism. a. Name three amino acids…
A: Phosphorylation of amino acids in protein is an important post-translational modification for…
Q: Total Number of NADH Obtained from one Pyruvate Molecule Total Number of FADH2 Obtained from one…
A: In respiring bacteria pyruvate is further oxidized after it is transported into mitochondria that is…
Q: A DNA codon has the sequence GAT. What is the resulting tRNA anti-codon in the translation process…
A: Codon is a sequence of three nucleotides present in DNA or mRNA (messenger RNA) molecule that…
Q: Draw and explain how SMC1 and SMC3 proteins form a heterodimer.
A: SMC1 and SMC3 proteins are involved in the formation of a heterodimer complex during the process of…
Q: 9. Which of the following changes would not affect a peptide GENSHIN? A. Heat B. Inorganic Salts C.…
A: Proteins are unbranched polymers constructed from 20 standard α-amino acids. They have four levels…
Q: what is the role of amino acids in purine metabolism?
A: Purine metabolism is described as a process in which different metabolic pathways are followed so as…
Q: 1. A 185g plant based burger is composed 55% carbohydrates, 35% protein and 20% fat. Calculate the…
A: Total energy of a food is expressed in calories. A calorie is a unit of how much energy is in a…
Q: Polyunsaturated fatty acids a). are solid at room temperature b). have carbon-carbon double bonds…
A: Fatty acids are carboxylic acids with long hydrocarbon chain. There are two types of fatty acids -…
Q: Which THREE statements are true about targetting proteins to the nudieua? Aln the cytoplasm, a…
A: Nuclear localization signals mediates the transport of proteins from the cytoplasm into the nucleus.
Trending now
This is a popular solution!
Step by step
Solved in 2 steps with 1 images
- Galactose 1-phosphate: UDP-glucose uridyltransferase (GALT) is an enzyme important for the catabolism of galactose. Patients with GALT deficiency present within days of birth with feeding difficulty, fatigue, jaundice and liver problems, and failure to thrive. In addition, a buildup of galactose and its metabolites are present in the bloodstream. GALT catalyzes the following reaction in galactose catabolism. NOTE that GALT is reversible!! Classify this enzyme and explain why you classified it in this way.The clinical signs of two types of galactosemia—galactokinase deficiency or UDPglucose: galactose 1-phosphate uridylyltransferase deficiency—are markedly different. Although both forms cause gastrointestinal pain after drinking milk, transferase deficiency also causes liver, kidney, spleen, and brain malfunction, as well as mortality. With each kind of enzyme shortage, what products accumulate in the blood and tissues? Estimate the relative toxicity of these goods based on the information provided above.The active site of lysozyme contains two amino acid residues essential for catalysis: Glu35 and Asp52. The pKa values of the carboxyl side chains of these residues are 5.9 and 4.5, respectively. What is the ionization state(protonated or deprotonated) of each residue at pH 5.2, the pH optimum of lysozyme? How can the ionization states of these residues explain the pH-activity profile of lysozyme shown below?
- Residue Asn 204 in the glucose binding site of hexokinase IV was mutated, in two separate experiments, to either Ala or Asp. The Asn → Ala mutant had a KM nearly 50-fold greater than the wild-type enzyme, and the Asn → Asp mutant had a 140-fold greater KM value than the wild-type enzyme. These mutations impact the intermolecular interactions between the enzyme and the glucose substrate.The amide functional group of the Asn side chain can form (dipole-dipole interactions, hydrodgen bonds, London Dispersion Interactions, or Ion-Dipole Interactions) with the hydroxyl groups of the glucose substrate and can potentially function as either a (hydrogen bond donor and/or acceptor, hydrogen bond donor, or hydrogen bond acceptor) . The methyl group of Ala cannot participate in hydrogen bond formation, which explains the (increase or decrease)…Residue Asn 204 in the glucose binding site of hexokinase IV was mutated, in two separate experiments, to either Ala or Asp. The Asn → Ala mutant had a KM nearly 50-fold greater than the wild-type enzyme, and the Asn → Asp mutant had a 140-fold greater KM value than the wild-type enzyme. These mutations impact the intermolecular interactions between the enzyme and the glucose substrate.The amide functional group of the Asn side chain can form with the hydroxyl groups of the glucose substrate and can potentially function as either a . The methyl group of Ala cannot participate in hydrogen bond formation, which explains the in glucose affinity as indicated by the higher KM for the mutant enzyme. The side chain of Asp could potentially serve as a , but…The clinical symptoms of two forms of galactosemia—deficiency of galactokinase or of UDPglucose: galactose 1-phosphate uridylyltransferase—show radically different severity. Although both types produce gastric discomfort after milk ingestion, deficiency of the transferase also leads to liver, kidney, spleen, and brain dysfunction and eventual death. What products accumulate in the blood and tissues with each type of enzyme deficiency? Estimate the relative toxicities of these products from the above information.
- UDP-glucuronosyltransferase enzymes bind the organic compound UDP-glucuronic acid (UDP-GA) in order to catalyse the transfer of a glucuronic acid group from UDP-GA to a drug molecule, releasing UDP from the active site as a product. UDP is then regenerated by the activity of another enzyme. What terms could be used to describe UDP-GA?The sedimentation value of aspartate transcarbamoylase decreases when the enzyme switches to the R state. On the basis of the allosteric properties of the enzyme, explain why the sedimentation value decreases.Mechanisms of catalysis : 2.1 Acid-base catalysis summary + example 2.2 Electrostatic catalysis summary + example 2.3 Covalent catalysis summary + example 2.4 Enzymen catalysis summary 2.5 Mechanism of chymotrypsin summary. These mechanisms involve several of the above-mentioned catalyses. In these summaries, do not just draw a diagram of the proposed mechanisms. It is more important to understand which reaction steps involve what kind of catalysis and how these help to reduce the activation energy needed for the reaction (e.g. a step in the reaction mechanism could be electrostatic catalysis to stabilise the transitions state) 2.6 Mechanism of lysozyme summary. These mechanisms involve several of the above-mentioned catalyses. In these summaries, do not just draw a diagram of the proposed mechanisms. It is more important to understand which reaction steps involve what kind of catalysis and how these help to reduce the activation energy needed for the reaction (e.g.…
- Within the body, CoQ 10 can be found in an oxidized or reduced form (also known as ubiquinone and ubiquinol). Describe how these structures differ and the biochemical role of coenzyme Q10.Using the appropriate graph and table above, explain what the N426S mutation appears to be doing to the enzyme’s function. Discuss the kinetic parameter changes and their meaning in this context, not the structure of the enzyme, which was not given to you.In what way is the observed mode of action of hexokinase consistent with the induced-fit theory of enzyme action?