ATP, like ADP and AMP, is a competitive inhibitor of NADH binding to malate dehydrogenase. Provide a structural explanation for this inhibition.
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ATP, like ADP and AMP, is a competitive inhibitor of NADH binding to malate dehydrogenase. Provide a structural explanation for this inhibition.
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- Based on your knowledge of the structure of NAD+ and an assumption that coenzyme dissociation is the rate limiting step of the alcohol dehydrogenase mechanism, hypothesize why a N249W mutation at the coenzyme binding site would increase the rate of catalysis.Extending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.The Effect of lodoacetic Acid on the Glyceraldehyde-3-P Dehydrogenase Reaction (Integrates with Chapters 4 and 14.) How might iodoacetic acid affect the glyceraldehydes-3-phosphate dehydrogenase reaction in glycolysis? Justify your answer.
- The Reactions and Meehanisms of the Leloir Pathway Write the reactions that permit galactose to be utilized in glycolysis. Write a suitable mechanism, tor one of these reactions.Complete oxidation of a 16-carbon fatty acid can yield 129 molecules of ATP Study Figure 19.2 and determine how many ATP molecules would be generated if a 16-carbon fatly acid were metabolized solely by the TCA cycle, in the form of S acetyl-CoA molecules.Examine the ActiveModel for alcohol dehydrogenase and describe the structure and function of the catalytic zinc center.
- ATP is a competitive inhibitor of NADH binding to malate dehydrogenase, as are ADP and AMP. Suggest a structural basis for this inhibitionThe tricarboxylate transport system supplies cytosolic acetyl-CoA for palmitate synthesis. What percentage of the NADPH required for palmitate synthesis is thereby provided?Briefly describe the role and location of each cofactor/coenzyme involved in the pyruvate dehydrogenase reaction. The five cofactors/coenzymes are TPP, Coenzyme A, Lipoate, FAD, and NAD! Please describe their roles in pyruvate dehydrogenase reaction and where they are each located!
- For each of the central pathway intermediates given below, calculate how many ATP equivalents can be generated by complete oxidation of the compound to CO2: 1. Acetyl-CoA 2. Pyruvate 3. GAP (glyceraldehyde-3-phosphate) And please explain why.Write a balanced equation for the conversion in the glyoxylate cycle of twoacetyl units, as acetyl-CoA, to oxaloacetate.Alpha-ketoglutarate dehydrogenase exhibits feedback inhibition by