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can you explain the catalytic mechanism of pyruvate dehydrogenase (complex)
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- The Effect of lodoacetic Acid on the Glyceraldehyde-3-P Dehydrogenase Reaction (Integrates with Chapters 4 and 14.) How might iodoacetic acid affect the glyceraldehydes-3-phosphate dehydrogenase reaction in glycolysis? Justify your answer.Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved residues in slightly different positions can change the catalytic rate of reaction.Extending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.
- Briefly describe the dual role of lipoic acid in the pyruvate dehydrogenase complexWhat are the similarities and differences between the reactions catalyzed by pyruvate dehydrogenase and a-ketoglutarate dehydrogenase?Briefly describe the role and location of each cofactor/coenzyme involved in the pyruvate dehydrogenase reaction. The five cofactors/coenzymes are TPP, Coenzyme A, Lipoate, FAD, and NAD! Please describe their roles in pyruvate dehydrogenase reaction and where they are each located!
- Distinguish between catalytic coenzymes and stoichiometric coenzymes in the pyruvate dehydrogenase complexBriefly describe the role and location of each cofactor/coenzyme involved in the pyruvate dehydrogenase reaction.Which one of the five steps of the pyruvate dehydrogenase complex reaction is most likely to be metabolically irreversible? Explain.