c) ogenase reducing acetaldehyde to ethanol, NADH donates a hydride to the carbonyl C, and the oxyanion is transiently stabilized by the Zn2+ divalent cation (see figure on first page), which is then protonated to form the final product. If one assumes that 4-iodopyrazole was bound similarly to the substrate, then which atoms of the inhibitor would be equivalent to the atoms of acetaldehyde? Mark the figure below with the atom of 4-iodopyrazole equivalent to each of the 3 heavy atoms in acetaldehyde. (Use the atom identifiers to identify each one unambiguously: N1, N2, C3, C4, C5, 14.) carbonyl C HC carbonyl O CH3 methyl C

Question
c)
ogenase reducing acetaldehyde to ethanol, NADH
donates a hydride to the carbonyl C, and the oxyanion is transiently stabilized by the Zn2+
divalent cation (see figure on first page), which is then protonated to form the final product.
If one assumes that 4-iodopyrazole was bound similarly to the substrate, then which atoms
of the inhibitor would be equivalent to the atoms of acetaldehyde? Mark the figure below
with the atom of 4-iodopyrazole equivalent to each of the 3 heavy atoms in acetaldehyde.
(Use the atom identifiers to identify each one unambiguously: N1, N2, C3, C4, C5, 14.)
carbonyl C
HC
carbonyl O
CH3
methyl C
Expand
Transcribed Image Text

c) ogenase reducing acetaldehyde to ethanol, NADH donates a hydride to the carbonyl C, and the oxyanion is transiently stabilized by the Zn2+ divalent cation (see figure on first page), which is then protonated to form the final product. If one assumes that 4-iodopyrazole was bound similarly to the substrate, then which atoms of the inhibitor would be equivalent to the atoms of acetaldehyde? Mark the figure below with the atom of 4-iodopyrazole equivalent to each of the 3 heavy atoms in acetaldehyde. (Use the atom identifiers to identify each one unambiguously: N1, N2, C3, C4, C5, 14.) carbonyl C HC carbonyl O CH3 methyl C

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