Parental strand -MutH -Newly made strand Mutl -Muts Incorrect MutH makes a cut in the nonmethylated strand. MutU (not shown) separates the DNA strands at the cleavage site, and an exonuclease (not shown) digests the nonmethylated strand until It passes the site where MutS is bound, removing the Incorrect base. base MutH cleavage site DNA polymerase fills in the vacant reglon. DNA ligase seals the end. The mismatch has been repalred correctly. А Н FIGURE 19.20 Mimatch repair in E. coli. In this example, the methylated adenine is designated with an m.
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Which of the three Mut proteins is responsible for ensuring that the mismatched base in the newly made daughter strand is the one that is removed?
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