quadrants contain leading strands.leftWhen DNA pol III onRNA primer, thus running out of template, it leaves a single-stranded gap between the last DNA nucleotide of the newlysynthesized daughter strand and the first nucleotide of theRNA primer (Figure 7.19). The pol III, having very low affin-ity for these DNA-RNA single-stranded gaps, is then replacedby DNA polymerase I (DNA pol I), which has high affin-ity for such gaps (Figure 7.19,). The DNA pol I removesnucleotides of the RNA primer onewith DNA nucleotides, beginning with the 5' nucleotide ofthe RNA primer and progressing in the 3' direction until allthe RNA nucleotides in the primer have been replaced byDNA nucleotides complementary to the template strand.The daughter strands in the upper left and lower rightquadrants shown in Figure 7.18 have a 5'-to-3' direction ofelongation that runs opposite to the direction of movementof the replication fork. These daughter strands are elongateddiscontinuously, in short segments, each of which is initiatedby an RNA primer. The discontinuously synthesized daughterstrand is called the lagging strand. Thus in Figure 7.18, thelower right and upper left quadrants of the replication bubblecontain lagging strands (see also step 5 of Figure 7.14)Reiji Okazaki detected the synthesis of short fragmentsof DNA in the replication of the lagging strand. He observedbyone and replaces themOkazakiFigure 7.18 The replicationbubble. Bidirectional expansionis driven by DNA synthesis ateach replication fork. One repli-some containing two DNA pol IIIenzymes operates at each fork toreplicate both daughter strands.Template DNAfragmentsDaughter DNAoricReplisome regionReplisome region13' 5Replication fork3(location ofReplication fork(location ofone replisome)3'3'5'5'3'one replisome)5'RNA primerDraw a second replication5'bubble to the right of the3'Leading strandLagging strandTone illustrated. As these twoLagging strand5'3'replication bubbles expandtoward one another, what kindof strand will each leadingLeading strand3'5'3'35' 3'5' i3'strand encounter when thebubbles make contact?21Okazaki fragmentsbaotDe 10oricBidirectional expansionof bubbled n0inin

Question
Asked Sep 29, 2019
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Please help me with the orange question. 

My answer is leading strand will encounter lagging strand. 

I dont know if it’s correct.

Thank you

quadrants contain leading strands.
left
When DNA pol III on
RNA primer, thus running out of template, it leaves a single-
stranded gap between the last DNA nucleotide of the newly
synthesized daughter strand and the first nucleotide of the
RNA primer (Figure 7.19). The pol III, having very low affin-
ity for these DNA-RNA single-stranded gaps, is then replaced
by DNA polymerase I (DNA pol I), which has high affin-
ity for such gaps (Figure 7.19,). The DNA pol I removes
nucleotides of the RNA primer one
with DNA nucleotides, beginning with the 5' nucleotide of
the RNA primer and progressing in the 3' direction until all
the RNA nucleotides in the primer have been replaced by
DNA nucleotides complementary to the template strand.
The daughter strands in the upper left and lower right
quadrants shown in Figure 7.18 have a 5'-to-3' direction of
elongation that runs opposite to the direction of movement
of the replication fork. These daughter strands are elongated
discontinuously, in short segments, each of which is initiated
by an RNA primer. The discontinuously synthesized daughter
strand is called the lagging strand. Thus in Figure 7.18, the
lower right and upper left quadrants of the replication bubble
contain lagging strands (see also step 5 of Figure 7.14)
Reiji Okazaki detected the synthesis of short fragments
of DNA in the replication of the lagging strand. He observed
by
one and replaces them
Okazaki
Figure 7.18 The replication
bubble. Bidirectional expansion
is driven by DNA synthesis at
each replication fork. One repli-
some containing two DNA pol III
enzymes operates at each fork to
replicate both daughter strands.
Template DNA
fragments
Daughter DNA
oric
Replisome region
Replisome region
1
3' 5
Replication fork
3
(location of
Replication fork
(location of
one replisome)
3'
3'5'
5'
3'
one replisome)
5'
RNA primer
Draw a second replication
5'
bubble to the right of the
3'
Leading strand
Lagging strand
T
one illustrated. As these two
Lagging strand
5'
3'
replication bubbles expand
toward one another, what kind
of strand will each leading
Leading strand
3'
5'
3'
3
5' 3'
5' i3'
strand encounter when the
bubbles make contact?
2
1
Okazaki fragments
baot
De 10
oric
Bidirectional expansion
of bubble
d n0
in
in
help_outline

Image Transcriptionclose

quadrants contain leading strands. left When DNA pol III on RNA primer, thus running out of template, it leaves a single- stranded gap between the last DNA nucleotide of the newly synthesized daughter strand and the first nucleotide of the RNA primer (Figure 7.19). The pol III, having very low affin- ity for these DNA-RNA single-stranded gaps, is then replaced by DNA polymerase I (DNA pol I), which has high affin- ity for such gaps (Figure 7.19,). The DNA pol I removes nucleotides of the RNA primer one with DNA nucleotides, beginning with the 5' nucleotide of the RNA primer and progressing in the 3' direction until all the RNA nucleotides in the primer have been replaced by DNA nucleotides complementary to the template strand. The daughter strands in the upper left and lower right quadrants shown in Figure 7.18 have a 5'-to-3' direction of elongation that runs opposite to the direction of movement of the replication fork. These daughter strands are elongated discontinuously, in short segments, each of which is initiated by an RNA primer. The discontinuously synthesized daughter strand is called the lagging strand. Thus in Figure 7.18, the lower right and upper left quadrants of the replication bubble contain lagging strands (see also step 5 of Figure 7.14) Reiji Okazaki detected the synthesis of short fragments of DNA in the replication of the lagging strand. He observed by one and replaces them Okazaki Figure 7.18 The replication bubble. Bidirectional expansion is driven by DNA synthesis at each replication fork. One repli- some containing two DNA pol III enzymes operates at each fork to replicate both daughter strands. Template DNA fragments Daughter DNA oric Replisome region Replisome region 1 3' 5 Replication fork 3 (location of Replication fork (location of one replisome) 3' 3'5' 5' 3' one replisome) 5' RNA primer Draw a second replication 5' bubble to the right of the 3' Leading strand Lagging strand T one illustrated. As these two Lagging strand 5' 3' replication bubbles expand toward one another, what kind of strand will each leading Leading strand 3' 5' 3' 3 5' 3' 5' i3' strand encounter when the bubbles make contact? 2 1 Okazaki fragments baot De 10 oric Bidirectional expansion of bubble d n0 in in

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Expert Answer

Step 1

DNA replication takes place in a bidirectional mode in which both strands are replicated simultaneously.  The top strand is present in 3’ to 5’ direction and bottom strand is present in 5’ to 3’ direction. Direction of DNA replication is 5’ to 3’ direction.

Step 2

DNA polymerase (deoxyribose nucleic acid) is able to add free nucleotides to the 3’ end of a growing strand or primer.  Certain length of template strand is required for DNA polymerase to synthesize a strand.  The leading strand is synthesized on the top strand and lagging strand is synthesized on the bottom strand. The synthesis of leading strand is continu...

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