Pioglitazone, a drug used to treat diabetes, causes some membrane-embedded portions of mitochondrial Complex I to separate from the rest of the protein that includes the matrix “arm.” Predict the effect of pioglitazone on electron transport and ATP production. The protonmotive force is decreased, leading to less ATP produced by ATP synthase

Pioglitazone, a drug used to treat diabetes, causes some membrane-embedded portions of mitochondrial Complex I to separate from the rest of the protein that includes the matrix “arm.” Predict the effect of pioglitazone on electron transport and ATP production. The protonmotive force is decreased, leading to less ATP produced by ATP synthase

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter2: Cell Physiology

Section: Chapter Questions

Problem 2TAHL

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When the antibiotic X is added to actively respiring mitochondria, several things happen: the yield of ATP decreases, the rate of O2 consumption increases, heat is released, and the pH gradient across the inner mitochondrial membrane increases. Does X act as an uncoupler or an inhibitor of oxidative phosphorylation? Explain the experimental observations in terms of the antibiotic’s ability to transfer K+ ions across the inner mitochondrial membrane.
The image shows the flow of electrons through electron carriers I, II, III, and IV within the mitochondrial inner membrane. The electronegativity of the protein carriers determines their capacity to attract electrons. Based on the image, which of the following best describes the electronegativity of the carriers and the synthesis and utilization of ATP during the electron-transfer process? Electron carrier I is the least electronegative, and electron carrier IV is the most electronegative. ATP is required for electron transfer between carriers. Electron carrier I is the most electronegative, and electron carrier IV is the least electronegative. ATP is not required for electron transfer between carriers. Electron carrier I is the most electronegative, and electron carrier IV is the least electronegative. ATP is utilized in a distinct reaction, not directly coupled with electron transfer. Electron carrier I is the least electronegative, and electron carrier IV is the most…
Which of the following statements is NOT true about the electron transport chain (ETC) and oxidative phosphorylation? A. Oxidative phosphorylation requires the enzyme complexes to be soluble in the mitochondrial matrix. B. If the proton gradient is too high, electrons will not move through the ETC. C. The movement of electrons down the ETC only happens if protons are pumped out of the mitochondrial matrix. D. Oxidative phosphorylation requires the mitochondrial intermembrane space to be more positively charged than the matrix. E. The free energy of the proton gradient can be used to create high energy bonds.
Which of the following statements is NOT true about the electron transport chain (ETC) and oxidative phosphorylation? (Only one answer applies) A. Oxidative phosphorylation requires the enzyme complexes to be soluble in the mitochondrial matrix. B. If the proton gradient is too high, electrons will not move through the ETC. C. The movement of electrons down the ETC only happens if protons are pumped out of the mitochondrial matrix. D. Oxidative phosphorylation requires the mitochondrial intermembrane space to be more positively charged than the matrix. E. The free energy of the proton gradient can be used to create high energy bonds.
The glycerol phosphate shuttle moves reducing equivalents (electrons) from the cytosol to the mitochondrial matrix. Which of the following is not a feature of this shuttle? a) Cytoplasmic glycerol phosphate dehydrogenase converts dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate. b) Mitochondrial glycerol phosphate dehydrogenase converts glycerol-3-phosphate to DHAP. c) Cytoplasmic NADH is oxidized to NAD+. d) Mitochondrial NAD+ is reduced to NADH. e) 1.5 ATPs are formed per cytoplasmic NADH shuttled.
What is the major route for protons moving from the inter membrane space back into the mitochondrial matrix during oxidative phosphorylation? 1. Protons carried across the membrane by a molecule of dinitrophenol 2. Protons are transported along with ADP by the ATP/ADP translocase.3. Protons enter the half channel in subunit a facing the inter membrane space and exit via the half channel facing the mitochondrial matrix. Choose 1 correct answer explain? Give typing answer with explanation and conclusion
Uncoupling agents are proteins spanning the inner mitochondrial membrane that allow protons to pass through the membrane and bypass the channel of ATP synthase. Describe the consequences to the proton gradient and ATP production.?
Oxidative phosphorylation generates ATP using the reducing power of [NADH, FADH2 or malate] to move electrons down a series of carriers to ultimately produce a [phosphate gradient or protons gradient] across the inner mitochondrial membrane, which is used by ATP synthase to make ATP. ATP synthase harnesses the energy stored in both [charge and concentration gradients or electostatic and van der waals interations] to achieve high energy phosphate bond synthesis. If the ion gradient across the inner membrane is dissipated by the expression of UCP1, ATP is not synthesized and [heat is generated or electron transport is blocked]. The final electron acceptor in the electron transport chain is [oxygen or carbon dioxide] with water as a product.
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It has taken considerable amounts of research to establish the number of protons pumped across the mitochondrial membrane at the various stages of electron transport.Would you expect to encounter difficulties in determining thenumber of protons pumped in electron transport across the thylakoid membrane? Why or why not?
NADH produced in the glycolytic pathway cannot enter the mitochondrial membrane, so the shuttle systems are utilized to deliver the electrons to the ETC. Using a flowchart, illustrate and differentiate the flow of the electrons in the ETC when electrons from cytosolic NADH are delivered to the ETC via the two shuttle systems.
Cyanide is a poisonous substance. Cyanide is a cytochrome c oxidase inhibitor that is competitive. The last enzyme of the electron transport chain in mitochondria is cytochrome c oxidase. One of the most common substrates for cytochrome c oxidase is oxygen.Would an increase in the concentration of oxygen affect the inhibitioncaused by cyanide?How would conditions in the mitochondrial intermembrane spacechange if cytochrome c oxidase and the electron transport chain are notfunctioning properly.. Explain why this change in conditions will be harmful to a cell.