The sequence of the MRNA SARS-CoV-2 vaccine from Pfizer/BioNTech contains several W residues (= 1-methyl-3'-pseudouridylyl). Why are these included? Explain. 50 GAGAAWAAAC ҸAGYAYYCҸY CҸGGYССССА СAGACYCAGA GAGAACCCGC CACCAYGYYC GYGYYCCYGG YGCYGCYGCC YC¥GG¥G¥CC AGCCAGYGYG 100 YGAACCYGAC CACCAGAACA CAGCWGCC¥C CAGCCWACAC CAACAGCYWW 150 ACCAGAGGCG YGYACYACCC CGACAAGGYG YYCAGAYCCA GCGYGCYGCA 200 CYCYACCCAG GACCYGYYCC YGCCYYYCYY CAGCAACGYG ACCYGGYYCC 250 ACGCCAYCCA CGYG¥CCGGC ACCAAYGGCA CCAAGAGAVY CGACAACCCC 300 GYGCYGCCCY YCAACGACGG GGYGYACYYY GCCAGCACCG AGAAGYCCAA 350 СAVСАWCAGA GGCWGGAWCY ФCGGCACCAC АCYGGACAGC AAGACCCAGA 400 GCCYGCYGAY CGYGAACAAC GCCACCAACG YGGYCAYCAA AGYGYGCGAG 450 YYCCAGYYCY GCAACGACCC CY¥CCYGGGC G¥CYACYACC ACAAGAACAA 500 CAAGAGCYGG AYGGAAAGCG AGYYCCGGGY GYACAGCAGC GCCAACAACY 550 GCACCYYCGA GYACGYGYCC CAGCCYWYCC YGAYGGACCY GGAAGGCAAG 600 CAGGGCAACY YCAAGAACCY GCGCGAGYYC GYGYYYAAGA ACAYCGACGG 650 CVACYYCAAG AYCVACAGCA AGCACACCCC VAYCAACCYC GYGCGGGAYC 700 YGCCYCAGGG CYYC¥CYGCY C¥GGAACCCC YGGYGGAYCY GCCCAYCGGC 750 AYCAACAYCA CCCGGYWYCA GACACYGCYG GCCCYGCACA GAAGCWACCY 800 GACACCYGGC GAWAGCAGCA GCGGAYGGAC AGCWGGYGCC GCCGCYVACY 850 AYGYGGGCYA CCYGCAGCCY AGAACCYYCC YGCYGAAGYA CAACGAGAAC 900 GGCACCAYCA CCGACGCCGW GGAYYGYGCY C¥GGAYCCYC YGAGCGAGAC 950 AAAGYGCACC CYGAAGYCCY YCACCG¥GGA AAAGGGCAWC VACCAGACCA 1000 GCAACYVCCG GGYGCAGCCC ACCGAAYCCA YCGYGCGGYW CCCCAAYAYC 1050 ACCAAWCYGV GCCCCVYCGG CGAGGYGYYC AAYGCCACCA GAVYCGCCYC 1100 YGYGYACGCC YGGAACCGGA AGCGGAYCAG CAAVYGCGYG GCCGACWACY 1150 CCGYGCYGYA CAACYCCGCC AGCYYCAGCA CCY¥CAAGYG CVACGGCGYG 1200 YCCCCVACCA AGCYGAACGA CCWG¥GCYYC ACAAACGYGY ACGCCGACAG 1250 CYYCGYGAYC CGGGGAGAYG AAGYGCGGCA GAWYGCCCCY GGACAGACAG 1300 GCAAGAYCGC CGACWACAAC VACAAGCYGC CCGACGACVW CACCGGCWG¥ 1350 GYGAYYGCCY GGAACAGCAA CAACCYGGAC VCCAAAGYCG GCGGCAACVA 1400 CAAVYACCYG VACCGGCYGW YCCGGAAG¥C CAAYCYGAAG CCC¥CGAGC 1450 GGGACAYCYC CACCGAGAYC VAYCAGGCCG GCAGCACCCC VYGYAACGGC 1500 GYGGAAGGCW VCAACWGCWA CY¥CCCACYG CAGYCCWACG GCVYYCAGCC 1550 CACAAAYGGC GYGGGCWAYC AGCCCWACAG AGYGGYGGYG CYGAGCYWCG 1600 AACYGCYGCA YGCCCCYGCC ACAGYGYGCG GCCCVAAGAA AAGCACCAAY 1650 CYCGYGAAGA ACAAAYGCGW GAACWYCAAC VYCAACGGCC YGACCGGCAC 1700 CGGCGYGCYG ACAGAGAGCA ACAAGAAGYW CCYGCCAYYC CAGCAGYVYG 1750 GCCGGGAVAV СССCGAVACC АCAGACGCCGWWAGAGAWCC ССAGACACWG 1800 GAAAYCCYGG ACAWCACCCC VYGCAGCWWC GGCGGAGWGW CWG¥GAYCAC 1850 CCCYGGCACC AACACCAGCA AYCAGGYGGC AGYGCVGVAC CAGGACGYGA 1900

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