MATLAB: An Introduction with Applications
MATLAB: An Introduction with Applications
6th Edition
ISBN: 9781119256830
Author: Amos Gilat
Publisher: John Wiley & Sons Inc
Bartleby Related Questions Icon

Related questions

Question

Testing the metabolic stability of compounds used in drugs is the cornerstone of new drug discovery. Two important values computed from the testing phase are the fraction of compound unbound to plasma (fup) and the fraction of compound unbound to microsomes (fumic). A key formula for assessing stability assumes that the fup/fumic ratio is 1. Pharmacologists at Pfizer Global Research and Development investigated this phenomenon and reported the results in ACS Medicinal Chemistry Letters (Vol. 1, 2010). The fup/fumic ratio was determined for each of 416 drugs in the Pfizer database. A graph describing the fup/fumic ratios is shown below.

  1. What type of graph is displayed?

  2. What is the quantitative variable summarized in the graph?

  3. Determine the proportion of fup/fumic ratios that fall above 1.

  4. Determine the proportion of fup/fumic ratios that fall below .4.

200
182
180
160
140
120
107
100
80
59
60
40
34
20
20
4
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
fup/fumic Ratio
Frequency
expand button
Transcribed Image Text:200 182 180 160 140 120 107 100 80 59 60 40 34 20 20 4 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 fup/fumic Ratio Frequency
Expert Solution
Check Mark
Knowledge Booster
Background pattern image
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
MATLAB: An Introduction with Applications
Statistics
ISBN:9781119256830
Author:Amos Gilat
Publisher:John Wiley & Sons Inc
Text book image
Probability and Statistics for Engineering and th...
Statistics
ISBN:9781305251809
Author:Jay L. Devore
Publisher:Cengage Learning
Text book image
Statistics for The Behavioral Sciences (MindTap C...
Statistics
ISBN:9781305504912
Author:Frederick J Gravetter, Larry B. Wallnau
Publisher:Cengage Learning
Text book image
Elementary Statistics: Picturing the World (7th E...
Statistics
ISBN:9780134683416
Author:Ron Larson, Betsy Farber
Publisher:PEARSON
Text book image
The Basic Practice of Statistics
Statistics
ISBN:9781319042578
Author:David S. Moore, William I. Notz, Michael A. Fligner
Publisher:W. H. Freeman
Text book image
Introduction to the Practice of Statistics
Statistics
ISBN:9781319013387
Author:David S. Moore, George P. McCabe, Bruce A. Craig
Publisher:W. H. Freeman