Textbook Problem

Answers to all problems are at the end of this book. Detailed solutions are available in the Student Solutions Manual, Study Guide, and Problems Book.

1. Calculate the Free Energy Change for Synthesis of a Polynucleotide

(Integrals with Chapter 3.) The synthesis of RNA can be summarized by the reaction:

$n\text{NTP}\to {\left(\text{NTP}\right)}_n+n{\text{PP}}_{\text{i}}$What is the $△$G°’_overall far synthesis of an RNA molecule 100 nucleotides in length, assuming that the $△$G°’ for transfer of an NMP from an NTP to the 3'-O of polynucleotide chain is the same as the $△$G' for Transfer of an NMP from an NTP to H₂O (Use data given in Table 3.3.)