The significance of the alteration in the given absorbance of nitrotyrosine after the addition of the substrate analog succinate at 430 nm is to be stated. Concept introduction: The concerted model suggests that subunits of enzymes are arranged in such connection in which any conformational change in any of the subunit is compulsorily granted to all the subunits.

Question

please very soon full explanation all parts please 1a. Add to this drawing the substrate molecule binding to the active site and be specific about the shape of the substrate molecule. Next to your drawing write the chemical properties of the substrate that are important for it to bind to the enzyme. 1b. If the amino acid serine present in the active site were to be mutated to valine, how will this mutation affect the enzyme’s activity? Explain in 30 words or less. 1c. Your colleague would like to design an inhibitor molecule for the normal version of this enzyme that targets the enzyme active site. What are two characteristics of the inhibitor that you would suggest they incorporate in order to allow it to maximally block the enzyme’s activity? Use 40 words or less.

Answer 1

Question

Chapter 10, Problem 33P

Interpretation Introduction

Interpretation:

The significance of the alteration in the given absorbance of nitrotyrosine after the addition of the substrate analog succinate at 430 nm is to be stated.

Concept introduction:

The concerted model suggests that subunits of enzymes are arranged in such connection in which any conformational change in any of the subunit is compulsorily granted to all the subunits.

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please very soon full explanation all parts please 1a. Add to this drawing the substrate molecule binding to the active site and be specific about the shape of the substrate molecule. Next to your drawing write the chemical properties of the substrate that are important for it to bind to the enzyme. 1b. If the amino acid serine present in the active site were to be mutated to valine, how will this mutation affect the enzyme’s activity? Explain in 30 words or less. 1c. Your colleague would like to design an inhibitor molecule for the normal version of this enzyme that targets the enzyme active site. What are two characteristics of the inhibitor that you would suggest they incorporate in order to allow it to maximally block the enzyme’s activity? Use 40 words or less.

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