Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Question
Chapter 10, Problem 9P
Interpretation Introduction
Interpretation:
The molecule that can enhance the ATCase inhibition other than CTP needs to be suggested.
Concept introduction:
ATCase is Aspartate Transcarbamoylase enzyme which is an allosteric enzyme. This function is the catalysis of the first step of synthesis of pyrimidines. It is composed of both regulatory and catalytic subunits.
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MULTIPLE CHOICE
In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not
A. decrease de novo pyrimidine synthesis
B. decrease de novo purine synthesis
C. decrease urate synthesis
D. increase PRPP levels (Phosphoribosyl pyrophosphate)
Pls help ASAP, thank you!
"Regulation of metabolic pathways most typically occurs at enzyme steps that are"
CTP inhibits ATCase; however, the inhibition is not complete. Can you suggest another molecule that might enhance the inhibition of ATCase?
Chapter 10 Solutions
Biochemistry
Ch. 10 - Prob. 1PCh. 10 - Prob. 2PCh. 10 - Prob. 3PCh. 10 - Prob. 4PCh. 10 - Prob. 5PCh. 10 - Prob. 6PCh. 10 - Prob. 7PCh. 10 - Prob. 8PCh. 10 - Prob. 9PCh. 10 - Prob. 10P
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