Biology - Study Guide
8th Edition
ISBN: 9780321501561
Author: Martha R. Taylor
Publisher: PEARSON EDUCATION (COLLEGE)
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Chapter 11, Problem 7TYK
Summary Introduction
Introduction: G proteins are bound to GPCR (G protein-coupled receptors) that are essential for triggering many signal transduction pathways. The G protein is a heterotrimer having three sub units, namely α, β, and γ. The α sub unit is responsible for activating many cascade reactions in the effector cells by the process of phosphorylation, while β and γ sub units dissociate and activate its target cells.
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Protein phosphorylation is commonly involved with all of thefollowing except(A) activation of receptor tyrosine kinases.(B) activation of protein kinase molecules.(C) activation of G protein-coupled receptors.(D) regulation of transcription by signaling molecules.
The activation of receptor tyrosine kinases is characterized by
a.
dimerization and phosphorylation
b.
a phosphorylation cascade
c.
channel protein shape change
d.
GTP hydrolysis
A drug that inhibits the kinase activity of AKT would MOST likely have which of the following effects?
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Chapter 11 Solutions
Biology - Study Guide
Ch. 11 - How do plant hormones (often called plant growth...Ch. 11 - Prob. 2IQCh. 11 - Label the parts in the following diagram of an...Ch. 11 - Prob. 4IQCh. 11 - a. What does a protein kinase do? b. What is a...Ch. 11 - Prob. 6IQCh. 11 - Prob. 7IQCh. 11 - Prob. 8IQCh. 11 - a. What can one conclude from the fact that the...Ch. 11 - Prob. 1SYK
Ch. 11 - Briefly describe the three stages of cell...Ch. 11 - Some signaling pathways alter a proteins activity;...Ch. 11 - Prob. 4SYKCh. 11 - Prob. 1TYKCh. 11 - Steroid hormones a. bind to cell-surface...Ch. 11 - Prob. 3TYKCh. 11 - Prob. 4TYKCh. 11 - Which of the following is a key difference between...Ch. 11 - Many human diseases (including bacterial...Ch. 11 - Prob. 7TYKCh. 11 - If a protein is activated by the addition of a...Ch. 11 - Prob. 9TYKCh. 11 - Prob. 10TYKCh. 11 - From studying the effects of epinephrine on liver...Ch. 11 - You are a Ca2+ ion in a typical animal cell. Where...Ch. 11 - Which of the following molecules is incorrectly...Ch. 11 - Prob. 14TYKCh. 11 - Prob. 15TYK
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- What is the function of Ras during tyrosine kinase cell signaling? a. It activates the opening of channel-linked receptors. b. It is an enzyme that synthesizes second messengers. c. It links the receptor protein to the MAP kinase pathway. d. It phosphorylates other enzymes as part of a pathway.arrow_forwardScaffold proteins (a) release kinases and phosphatases into the extracellular fluid (b) bind G proteins to cell membranes (c) increase accuracy but slow signaling cascades (d) organize groups of intracellular signaling moleculesinto signaling complexes (e) are transcription factors found mainly in plant cellsarrow_forwardThis inhibatory kinase phosphorylates an inactive M-Cdk. a) M-kinase b) Wee1 c) CAK d) Cdc25arrow_forward
- Hydrophobic signaling molecules act by a. binding to plasma proteins b. starting second messenger systems c. binding to receptors inside the cell d. starting action potentialsarrow_forwardA particular drug inhibits the protein kinase that is responsible for phosphorylating the CREB protein. How would this drug affect the following events? A. The ability of the CREB protein to bind to CREs B. The ability of extracellular hormones to enhance cAMP levels C. The ability of the CREB protein to stimulate transcription D. The ability of the CREB protein to dimerizearrow_forwardAll except which one of the following can be a function of the heterotrimeric G protein of a GPCR? a) inhibit adenylyl cyclase b) activate adenylyl cyclase c) act as a protein kinase d) activate ion channelsarrow_forward
- For cellular transduction, why is it useful that phosphorylation cascades have a series of protein kinases? a. they amplify the original signal b. they always lead to the same cellular response c. the number of molecules used is small and fixed d. they are cell specificarrow_forwardA mutation in Ras that prevents Ras from hydrolyzing GTP. Would cause? Why? A. Increased proliferation B. Decreased proliferationarrow_forwardThe activation of receptor tyrosine kinases is characterized by(A) dimerization and phosphorylation.(B) dimerization and IP3 binding.(C) a phosphorylation cascade.(D) GTP hydrolysis.arrow_forward
- During cell signaling, binding of a ligand to the outside of a cell leads to: A. A signal being sent inside the cell B. The ligand being transported into the cell C. A and B D. None of the abovearrow_forwardA biochemist is designing a new drug that will mimic the shape and function of a particular intercellular signaling molecule. Therefore she must produce a molecule that will bind to the receptor protein and... A. produce a cellular response by altering the Na+/K+ pump located near the receptor site. B. induce a change in the receptor molecule shape, which will ultimately prevent a cellular response. C. induce a change in the receptor molecule shape, which will ultimately produce a cellular response. D. induce a change in the phospholipid bilayer that causes a polar reversal allowing the molecules to be endocytose (engulfed).arrow_forwardIn intercellular signaling pathways, some receptor proteins can also act as a transcription factor (changing gene expression), because these receptors are ________. A) Group of answer choices B) Intracellular receptors C) Membrane bound receptors D) G protein coupled receptors E) Enzyme linked receptors F) Fast ligand-gated ion channelsarrow_forward
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