Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 12, Problem 2P

Methanol is highly toxic, not because of its own biological activity but because it is converted metabolically to formaldehyde, through action of alcohol dehydrogenase. Part of the medical treatment for methanol poisoning involves administration of large doses of ethanol. Explain why this treatment is effective.

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Another antidote for methanol poisoning is fomepizole, which is an aldehyde dehydrogenase (ADH) inhibitor. Would fomepizole be more or less effective than ethanol? Explain your reasoning.
Alcohol dehydrogenase is the enzyme that converts alcohols to aldehydes or ketones. Explain how methanol poisoning can be treated with ethanol.
Alcohol dehydrogenase catalyzes the oxidation of an alcohol to the next highest state of oxidation, an aldehyde. How does this partially explain the toxicity of methanol?
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