Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
Question
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Chapter 12, Problem 3P
Interpretation Introduction

Interpretation:

We have to find out the glycolytic intermediates that would be formed when glyceraldehydes-3-phosphate dehydrogenase is inhibited with iodoacetate reacting with its active cysteine sulfurhydral group.

Concept Introduction:

Glyceraldehydes-3-phosphate dehydrogenase inhibition causes an increase in the production of Uridine Diphosphate N-Acetylglucosamine (UDP-GlcNAc) that could cause increase in glycolytic metabolite glyceraldehyde 3-phosphate. This can activate the advanced glycation end product pathway by activating methylglyoxal, an intracellular advanced glycation end product.

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