Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 13, Problem 11P
Compare and contrast promoters and enhancers with respect to their location (upstream versus downstream), orientation, and distance (in base pairs) relative to a gene they regulate.
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Explain how the expression of a single gene can be quickly,efficiently,and specifically shut down at the transcriptional,posttranscriptional,and posttranslational stages through thecoordinated expression of a transcriptional repressor, an miRNA,and a ubiquitin ligase.
Can methylation state of the promoter influence the level of gene expression? Briefly describe how gene expression changes based on the promoter methylation level
Please describe the regulatory role of enhancers that binds to responsible regulators to activate the target gene at a given time and place through comparing different organisms according to the presence of regulatory sequences
Chapter 13 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 13 - 13.1 Devoting a few sentences to each, describes...Ch. 13 - 13.2 Describe and give an example (real or...Ch. 13 - What is meant by the term chromatin remodeling?...Ch. 13 - 13.4 What general role does acetylation of histone...Ch. 13 - 13.5 Describe the roles of writers, readers, and...Ch. 13 - Outline the roles of RNA in eukaryotic gene...Ch. 13 - 13.7 What are the roles of the Polycomb and...Ch. 13 - Most biologists argue that the regulation of gene...Ch. 13 - Compare and contrast the transcriptional...Ch. 13 - The term heterochromatin refers to heavily...
Ch. 13 - 13.11 Compare and contrast promoters and enhancers...Ch. 13 - 13.12 What are the different chromatin...Ch. 13 - 13.13 Define epigenetics, and provide examples...Ch. 13 - What is one proposed role for lncRNAs?Ch. 13 - 13.15 What are the sources of dsRNA? Diagram the...Ch. 13 - How does dsRNA lead to posttranscriptional gene...Ch. 13 - 13.17 A hereditary disease is inherited as an...Ch. 13 - Prob. 18PCh. 13 - Prob. 19PCh. 13 - 13.20 A muscle enzyme called ME is produced by...Ch. 13 - Using the components in the accompanying diagram,...Ch. 13 - 13.22 The majority of this chapter focused on gene...
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- Explain why knowing the orientation of a promoter is critical when determining the amino acid sequence of an encoded protein.arrow_forwardBriefly describe how the transcript beginning at the lambda PRe promoter can inhibit expression of the cro gene.arrow_forwardIf a gene is repressible and under positive control, what kind of effector molecule and regulatory protein are involved in its regulation? Explain how the binding of the effector molecule affects the regulatory protein.arrow_forward
- a. Use circles for activators and squares for repressors. Draw the shapes bound to each promoter region. b. Under the word gene write “ON” or “OFF” to indicate if the gene is transcribed or not under the different conditions.arrow_forwardExplain how a gene knockdown reagent, such as RNAi or a morpholino, could interfere with expression of a gene without affecting the rate of transcription of the target gene.arrow_forwardyou design an ideal promoter for a gene to be highly expressed in E. coli cells? Describe strategies and explainarrow_forward
- Compare and contrast how activators, coactivators, repressors,TFIID, and mediator play a role in gene regulation.arrow_forwardDescribe three (3) ways in which the primary transcript is modified as it is converted to mRNA.arrow_forward"Promoter is unmethylated, and gene can be transcribed" Illustrate this diagramtically ?arrow_forward
- Give two examples of how gene expression may be repressed without altering the coding sequence.arrow_forwardWhat are the advantages of having multiple types of promoters and enhancers?arrow_forwardDiscuss how the expression of a protein can be regulated post transcription in eukaryotic cells through, using the following key terms: Degradation of mRNA (two ways) Blocking translation Degradation of the proteinarrow_forward
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