Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 13, Problem 22P
The majority of this chapter focused on gene regulation at the transcriptional level, but the quantity of functional protein product in a cell can be regulated in many other ways as well (see Figure
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Eukaryotes have a multitude of ways of regulating gene expression. Why are all these regulatory mechanisms necessary to the functioning of a eukaryotic organism?
Explain using leucine zipper motifs as an example, how protein-protein interactions between
transcription factors containing such motifs can generate diversity in transcriptional activation.
Refer to the recognition of DNA elements in gene promoters to justify your answer. Assume
transcription factor A binds to DNA element A’, transcription factor B binds to DNA element B’, and
so forth.
What are the functions of transcriptional activator proteins and repressor proteins? Explain how they work at the molecular level.
Chapter 13 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 13 - 13.1 Devoting a few sentences to each, describes...Ch. 13 - 13.2 Describe and give an example (real or...Ch. 13 - What is meant by the term chromatin remodeling?...Ch. 13 - 13.4 What general role does acetylation of histone...Ch. 13 - 13.5 Describe the roles of writers, readers, and...Ch. 13 - Outline the roles of RNA in eukaryotic gene...Ch. 13 - 13.7 What are the roles of the Polycomb and...Ch. 13 - Most biologists argue that the regulation of gene...Ch. 13 - Compare and contrast the transcriptional...Ch. 13 - The term heterochromatin refers to heavily...
Ch. 13 - 13.11 Compare and contrast promoters and enhancers...Ch. 13 - 13.12 What are the different chromatin...Ch. 13 - 13.13 Define epigenetics, and provide examples...Ch. 13 - What is one proposed role for lncRNAs?Ch. 13 - 13.15 What are the sources of dsRNA? Diagram the...Ch. 13 - How does dsRNA lead to posttranscriptional gene...Ch. 13 - 13.17 A hereditary disease is inherited as an...Ch. 13 - Prob. 18PCh. 13 - Prob. 19PCh. 13 - 13.20 A muscle enzyme called ME is produced by...Ch. 13 - Using the components in the accompanying diagram,...Ch. 13 - 13.22 The majority of this chapter focused on gene...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- name TWO mechanisms of control of gene expression that are only used by eukaryotes and discuss why each of those mechanisms wouldn’t be possible in prokaryotes.arrow_forwardA genon wide analyst of human genome indicated that approximately 1500 genes encoded transcription factors that are important for sequence specific gene expression. based on this information approximately what percentage of the protein coding genes in human belong to the transcription factors? A. 15% B. 5% C. 7.5% D.1.5%arrow_forward• All nuclei in multicellular animals' cells have the exact identical genes. However, the sets of genes transcribed in a cell varies dramatically from one cell to the next. Explain how gene transcription patterns are regulated in various cell types.• Describe one type of gene regulation that occurs after transcription is completed.arrow_forward
- Please answer both questions Explain five ways that eukaryotic gene regulation is more complex than bacterial gene regulation? Mutations in the promoter region of the B-globin gene indicate that some areas are more sensitive than others. When mutations occur in consensus sequences(modular elements such as GC box, CAAT box, and TATA box), does transcription usually increase or decrease? Explain.arrow_forwardYou are teaching a class on the regulation of eukaryotic gene expression. In order to demonstrate this complex process, you decide to draw for the class a typical eukaryotic gene/transcription unit with its major regions, such as the promoter regions, where the RNA polymerase II and transcription factors would bind From the list given - choose all components that you think are part of a typical eukaryotic gene From the list given - choose all the regulatory sequences that you think would control the expression of this eukaryotic gene From the list given - choose all of the regulatory proteins that would bind the eukaryotic gene to control its expressionarrow_forwardCompare and contrast the transcriptional regulation of GAL genes in yeast with that of the lac genes in bacteria.arrow_forward
- The nucleus of a eukaryotic cell is much larger than a bacterium, and it contains much more DNA. As a consequence, a transcription regulator in a eukaryotic cell must be able to select its specific binding site from amongmany more unrelated sequences than does a transcription regulator in a bacterium. Does this present any special problems for eukaryotic gene regulation?arrow_forwardIn response to potentially toxic substances (e.g., high levels of iron), eukaryotic cells often use translational or posttranslational regulatory mechanisms to prevent cell death, rather than using transcriptional regulatory mechanisms. Explain why.arrow_forwardBriefly explain How does post-transcriptional regulation work in prokaryotic and eukarrow_forward
- A crucial step in the regulation of many bacterial genes is the binding of RNA polymerase to DNA at the promoter. Why might it be advantageous for bacteria to regulate the expression of their genes at this particular step?arrow_forwardWhat analogies can you draw between transcriptionaltrans-acting factors that activate gene expression in eukaryotes and the corresponding factors in bacteria? Givean examplearrow_forwardCompare the control of gene regulation in eukaryotes and prokaryotes at the level of initiation of transcription. How do the regulatory mechanisms work? What are the similarities and differences in these two types of organisms in terms of the specific components of the regulatory mechanisms? Address how the differences or similarities relate to the biological context of the control of gene expression.arrow_forward
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