Concept explainers
(a)
Interpretation:
The most sensitive member of the ASIC family to toxin needs to be determined.
Concept introduction:
The acid sensing ion channels which are commonly known as ASIC are the proton sensing channels present in the central nervous system which are reactive towards a variety of complex behaviors such as fear, anxiety, pain, depression, leaning and sensitivity.ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, and ASIC4 are six different subunits of such acid sensing ion channels.
(b)
Interpretation:
Whether the effect of the toxin is reversible or irreversible needs to be explained.
Concept introduction:
The acid sensing ion channels which are commonly known as ASIC are the proton sensing channels present in the central nervous system which are reactive towards a variety of complex behaviors such as fear, anxiety, pain, depression, leaning and sensitivity.
(c)
Interpretation:
The percentage of PcTx1 that yields 50% inhibition of the sensitive channel needs to be determined.
Concept introduction:
The acid sensing ion channels which are commonly known as ASIC are the proton sensing channels present in central nervous system which are reactive towards a variety of complex behaviors such as fear, anxiety, pain, depression, leaning and sensitivity.
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