Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Question
Chapter 13.4, Problem 1BC
Summary Introduction
To analyze:
Drugs that inhibit protein kinases be used to combat cancer.
Introduction:
The protein kinase is the kinase enzyme, which modifies other molecules. They mostly add the phosphate group to the proteins, which result in activating or declination in the protein function.
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Chapter 13 Solutions
Principles of Biology
Ch. 13.1 - Prob. 1CCCh. 13.1 - Prob. 2CCCh. 13.1 - Prob. 1TYKCh. 13.1 - Prob. 2TYKCh. 13.2 - Prob. 1CCCh. 13.2 - Prob. 2CCCh. 13.2 - Prob. 1TYKCh. 13.2 - Prob. 2TYKCh. 13.3 - Prob. 1CCCh. 13.3 - Prob. 1TYK
Ch. 13.4 - Prob. 1CCCh. 13.4 - Prob. 1BCCh. 13.4 - Prob. 2CCCh. 13.4 - Prob. 3CCCh. 13.4 - Prob. 4CCCh. 13.4 - Prob. 1TYKCh. 13.4 - Prob. 2TYKCh. 13 - A mutation removes a single base pair within the...Ch. 13 - Prob. 2TYCh. 13 - Prob. 3TYCh. 13 - Prob. 4TYCh. 13 - Prob. 5TYCh. 13 - Prob. 6TYCh. 13 - Prob. 7TYCh. 13 - Prob. 8TYCh. 13 - Prob. 9TYCh. 13 - Prob. 10TYCh. 13 - Prob. 1CCQCh. 13 - Prob. 2CCQCh. 13 - Prob. 3CCQCh. 13 - Prob. 1CBQCh. 13 - Prob. 2CBQ
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- Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please explain in detailsarrow_forwardWhat would be the effect of inhibiting the kinase?arrow_forwardCan we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb? If so, how can this be?arrow_forward
- Another model, the random model, proposes that any cell in a malignant tumor has the potential to form a new tumor. Does the cancer stem cell hypothesis contradict this idea?arrow_forwardFigure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is permanently activated, resulting in unregulated cell division. Lapatinib, a drug used to treat breast cancer, inhibits HER2 receptor tyrosine kinase autophosphorylation (the process by which the receptor adds phosphates onto itself), thus reducing tumor growth by 50 percent. Besides autophosphorylation, which of the following steps would be inhibited by Lapatinib? Signaling molecule binding, dimerization, and the downstream cellular response. Dimerization, and the downstream cellular response. The downstream cellular response. Phosphatase activity, dimerization, and the downsteam cellular response.arrow_forwardFigure 9.10 In certain cancers, the GTPase activity of the RAS G-protein is inhibited. This means that the RAS protein can no longer hydrolyze GTP into GDP What effect would this have on downstream cellular events?arrow_forward
- What are stem cells? Which stem cell treatment can form a benign tumor? Please explain how benign tumor can form from the stem cell therapy?arrow_forwardDescribe and connect five different outcomes that could occur due to the loss of FMRP function in the cell in the figure provided.arrow_forwardCan we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb? If so, how is this possible?arrow_forward
- Which of the following statements are correct about cytoplasmic signaling in cancer cells? Multiple answers. A. Only minor modifications of cell control machinery are required for normal cells to become highly proliferating cancer cells B. Immediate early genes are induced in the presence of protein synthesis inhibitors C. Many immediate -early genes are oncogenes D. Delayed early genes are highly expressed in the presence of protein synthesis inhibitors E. Delayed early genes are highly expressed in normal cells in the absence of growth factorsarrow_forwardWhich of the following statements correctly describes a characteristic of tumor-suppressor gene? a) they are frequently overexpressed in cancerous cells. b) they are cancer-causing genes introduced into cells by viruses. c) they encode proteins that help prevent uncontrolled cell growth. d) they often encode proteins that stimulate the cell cycle.arrow_forwardExplain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and how might gene therapy or other drug interventions inhibit the growth of a tumor?arrow_forward
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