Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 13.4, Problem 2TYK
Summary Introduction
Introduction:
The tumor suppressor gene, as the name suggest supresses the formation of the tumors. This gene prevents unnecessary division and growth of the damaged cell.
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Which of the following is not an example of tumor-suppressor gene?
A.
p53 gene
B.
Rb gene
C.
DCC gene
D.
Ras GTPase
it is not c
Which of the following statements correctly describes a characteristic of tumor-suppressor gene?
a) they are frequently overexpressed in cancerous cells.
b) they are cancer-causing genes introduced into cells by viruses.
c) they encode proteins that help prevent uncontrolled cell growth.
d) they often encode proteins that stimulate the cell cycle.
Which of the following is not a tumor suppressor gene?
a.RET
b.RB
c.BRCA1
d.BRCA2
Chapter 13 Solutions
Principles of Biology
Ch. 13.1 - Prob. 1CCCh. 13.1 - Prob. 2CCCh. 13.1 - Prob. 1TYKCh. 13.1 - Prob. 2TYKCh. 13.2 - Prob. 1CCCh. 13.2 - Prob. 2CCCh. 13.2 - Prob. 1TYKCh. 13.2 - Prob. 2TYKCh. 13.3 - Prob. 1CCCh. 13.3 - Prob. 1TYK
Ch. 13.4 - Prob. 1CCCh. 13.4 - Prob. 1BCCh. 13.4 - Prob. 2CCCh. 13.4 - Prob. 3CCCh. 13.4 - Prob. 4CCCh. 13.4 - Prob. 1TYKCh. 13.4 - Prob. 2TYKCh. 13 - A mutation removes a single base pair within the...Ch. 13 - Prob. 2TYCh. 13 - Prob. 3TYCh. 13 - Prob. 4TYCh. 13 - Prob. 5TYCh. 13 - Prob. 6TYCh. 13 - Prob. 7TYCh. 13 - Prob. 8TYCh. 13 - Prob. 9TYCh. 13 - Prob. 10TYCh. 13 - Prob. 1CCQCh. 13 - Prob. 2CCQCh. 13 - Prob. 3CCQCh. 13 - Prob. 1CBQCh. 13 - Prob. 2CBQ
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- Another model, the random model, proposes that any cell in a malignant tumor has the potential to form a new tumor. Does the cancer stem cell hypothesis contradict this idea?arrow_forwardWhat is the difference between a proto-oncogene and a tumor-suppressor gene?arrow_forward________ are changes to the nucleotides in a segment of DNA that codes for a protein. a. Proto-oncogenes b. Tumor suppressor genes c. Gene mutations d. Negative regulatorsarrow_forward
- Normal (nonmutant) tumor-suppressor genes often functiona. as negative regulators of cell division.b. in the maintenance of genome integrity.c. in the stimulation of cell division.d. as both a and b.arrow_forwardDescribe, using specific examples, the differences in how a growth factor gene and a tumor suppressor gene can become oncogenes.arrow_forwardDefine tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene expected to behave as a recessive gene?arrow_forward
- How can a mutation in a tumor-suppressor gene contribute to the development of cancer?arrow_forwardWhat are the key steps of transformation, tumorigenesis and metastasis on a cellular and tissue level.arrow_forwardCells in a tumor contain mutated copies of a particular gene that promotes tumor growth. Gene therapy can be used to introduce a normal copy of this gene into the tumor cells. Would you expect this therapy to be effective if the mutated gene were an oncogene? A tumor-suppressor gene? Explain your reasoning.arrow_forward
- Describe the difference between a tumor suppressor and an oncogene with respect to the actual causes of cancer.arrow_forward"In the cellular regulatory pathways that control cell growth and proliferation, the products of oncogenes are stimulatory components and the products of tumor suppressor genes are inhibitory components" is true or false.arrow_forwardWhich of the following types of mutations would be advantageous to a cancer cell (select all that apply)? A. An inactivating mutation in a tumor suppressor gene B. Methylation of the promoter of a tumor suppressor gene C. An inactivating mutation in an oncogene D. Mutation that inactivated DNA repair gene E. An inactivating mutation in an oncogenearrow_forward
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