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The pedigree belowtraces the inheritance of alkaptonuria, a biochemical disorder. Affected individuals, indicated here by the colored circles and squares, are unable to
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Campbell Biology (10th Edition)
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- Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?arrow_forwardDoes the phenotype indicated by the red circles and squares in this pedigree show an inheritance pattern that is autosomal dominant, autosomal recessive, or X-linked?arrow_forwardPedigree Analysis Is a Basic Method in Human Genetics Using the pedigree provided, answer the following questions. a. Is the proband male or female? b. Is the grandfather of the proband affected? c. How many siblings does the proband have, and where is he or she in the birth order?arrow_forward
- For this pedigree, give the most likely mode of inheritance, assuming that the trait is rare. For the pedigree, what is the probability that III-4 and III-5 will have a boy AND he will be affected?arrow_forwardThe second pedigree involves albinism, an autosomal recessive trait. A couple has a son with normal pigmentation, a daughter with normal pigmentation, and an albino son. Another couple has three children, a son with normal pigmentation and two daughters with normal pigmentation. The daughter from the first couple marries the man from the second couple and they have three children together: an albino son, an albino daughter, and a daughter with normal pigmentation.Draw the pedigree on the next pagearrow_forwardThe pedigree below shows that inheritance of a disease that is caused by a late onset, dominant, autosomal mutation that is rare, but only 50% penetrant. The gene that is mutated in the disease is linked at a distance of 10 cm to a microsatellite marker that has alleles numbered 1, 2, and 3. The marker alleles detected in each individual are indicated below. What is the probability that individual A will develop the disease? Explain using an illustration of this occurs.arrow_forward
- Acatalasia is caused by a rare autosomal recessive gene. In heterozygous condition catalase activity is decreased slightly. A woman with a normal catalase activity have a husband with low catalase activity. What is the probability of children birth without anomaly in the family, if grandparents from both sides have reduced activity of catalase? Diagram the cross and mention the genotypes of all individuals in the family?arrow_forwardThe following pedigree illustrates the inheritance of ringed hair, a condition in which each hair is differentiated into light and dark zones. What mode or modes of inheritance are possible for the ringed-hair trait in this family?arrow_forwardThe pedigree below shows three generations of a family that carries albinism, an autosomal recessive genetic disease. In the third generation, a child was born with albinism but the genotypes of the rest of the family are unknown. No other family members have the disease. Assume normal, Mendelian genetics with no new mutations. What are the genotypes of the parents of the affected child? A) There is not enough information to determine their genotypes B) Both are homozygous for albinism C) One is hemizygous and one is heterozygous for albinism D) Both are heterozygous for albinism E) One is homozygous and one is heterozygous for abinismarrow_forward
- Human Biology (MindTap Course List)BiologyISBN:9781305112100Author:Cecie Starr, Beverly McMillanPublisher:Cengage LearningHuman Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning