(a)
To determine: The method of synthesis of given compounds by reaction of Grignard reagent and an epoxide.
Interpretation: The method of synthesis of given compounds is to be stated by reaction of Grignard reagent and an epoxide.
Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted
(b)
To determine: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent.
Interpretation: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent is to be stated.
Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.
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Organic Chemistry (9th Edition)
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