Action of insulin binding and EGF binding on the chimeric receptor should be determined. Concept introduction: The cell-surface receptors for EGF and insulin are thought to have the same origin because of the similarity in cysteine-rich residues in their EC domains. Moreover, they both have tyrosine kinase domains. The only difference is found in their catalytic site, which is specific for ligands and biological functions.

Question

Want to see the full answer?

Answer 1

Question

Chapter 14, Problem 15P

Interpretation Introduction

Interpretation:

Action of insulin binding and EGF binding on the chimeric receptor should be determined.

Concept introduction:

The cell-surface receptors for EGF and insulin are thought to have the same origin because of the similarity in cysteine-rich residues in their EC domains. Moreover, they both have tyrosine kinase domains. The only difference is found in their catalytic site, which is specific for ligands and biological functions.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Describe a mechanism by which a steroid hormone might act to increase intracellular levels of cyclic AMP. Match the words in the left column to the appropriate blanks in the sentences on the right. activate decrease inhibit repressed induced increase Reset Help Since steroid hormone-receptor complexes specific genes, a steroid hormone could in principle transcription of the gene for adenylate cyclase and, hence, steady-state level of this enzyme. Other possibilities could include synthesis of a phosphodiesterase inhibitor or synthesis of cAMP phosphodiesterase. the transcription of the

In expressing therapeutic proteins (check all that apply): O Bacteria could be used if you want the protein's disulfide bonds formed before secretion from the bacterial cell. The N-terminal signal sequence and the C chain of insulin must be cleaved off in the rough ER before it's active. O Proteolytic protein maturation can be performed by mammalian cells. □ One of the required modifications to preproinsulin, before it's mature, is glycosylation. Both preproinsulin and proinsulin are inactive proteins.

Explain well. Asap