HUMAN HEREDITY (LL)-W/MINDTAP ACCESS
11th Edition
ISBN: 9781305717022
Author: Cummings
Publisher: CENGAGE L
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Chapter 15, Problem 14QP
Summary Introduction
To determine: The methods to determine the function of a gene that has been cloned.
Introduction: For the study of a genetic disorder, scientists must know the location of the gene and the normal function of the protein encoded by this gene. The other essential point is to know about the mutant gene or protein that produces the disease
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It has been suggested that it would make the study of human diseases easier if cloned transgenic animals
were produced that carried faulty versions of human genes (e.g., the gene that causes cystic fibrosis).
a. Why would such animals be useful in medical research? :
b. What ethical questions are raised by the creation of such transgenic animals?
Give a schematic diagram of how we can Treatment Down's syndrome by using gene therapy? Please answer at your own words,please..
You’ve made your construct and placed it into E. coli! Congratulations, you have made a transgenic organism. Your investors will want to know about quality control.
How will you check that the correct piece of DNA is in your vector?
How will you check to make sure the gene is transcribed?
How will you check to make sure that the GasP protein is made in E. coli?
Your investors are concerned that the GasP protein might not be sufficiently produced under normal laboratory conditions. They suggest controlling the transcription of the gasP gene using a chemical that will “trigger” its transcription.
What type of promoter could be used?
What chemical will you use to control transcription?
How does this method of control work?
Chapter 15 Solutions
HUMAN HEREDITY (LL)-W/MINDTAP ACCESS
Ch. 15.1 - Who Owns Your Genome? John Moore, an engineer...Ch. 15.1 - Who Owns Your Genome? John Moore, an engineer...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - The gene controlling ABO blood type and the gene...Ch. 15 - Hemophilia and color blindness are both recessive...Ch. 15 - Prob. 3QPCh. 15 - Prob. 4QP
Ch. 15 - How many nucleotides does the human genome...Ch. 15 - Which of the following best describes the process...Ch. 15 - Which of the following is NOT an activity carried...Ch. 15 - Prob. 8QPCh. 15 - Prob. 9QPCh. 15 - What percentage of the DNA in the genome actually...Ch. 15 - When the human genome sequence was finally...Ch. 15 - One unexpected result of the sequencing of the...Ch. 15 - Prob. 13QPCh. 15 - Prob. 14QPCh. 15 - Prob. 15QPCh. 15 - Prob. 16QPCh. 15 - Prob. 17QP
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- Let’s say, you want to deliver a gene into a cell and in your lab, there are lot of options available to do that. Describe five different options that you can use to deliver that gene.arrow_forwardIn the 1996 movie Multiplicity, Doug (Michael Keaton) is a construction worker who wants to spend more time with his family. He meets a friendly scientist (aren't we all?) who has a method for cloning humans. Doug decides to make a clone of himself who can do his work while he spends time with his family. The clone, named "Two", seems great at first, but later develops some functional problems. Two gets tired of working and clones himself to make "Three" to take over. Three then leads to "Four". Each successive clone seems to have an increasing number of issues in function. Ignoring ethical and technical considerations with making adult clones of a human, is there any logical or genetic validity to the premise that make a clone might create problems? If so, what might some of those problems be?arrow_forwardA couple with a child affected with DBA undergoes in vitro fertilization (IVF) and genetic testing of the resulting embryos to ensure that the embryos will not have DBA. However, they also want the embryos screened to ensure that the one implanted can serve as a suitable donor for their existing child. Their plan is to have stem cells from the umbilical cord of the new baby transplanted to their existing child with DBA, thereby curing the condition. What are the ethical pros and cons of this situation?arrow_forward
- I believe that there are many good things that can come out of people getting to design their baby’s genetic material. But there are also many bad things as well. From the article by Bio medical about the pros and cons of having a designer baby it states that a pro is that this type of engineering can “ might help prevent genetic diseases such as Alzheimer’s, Huntington’s Disease, down syndrome, Spinal Muscular Atrophy, and many others”. I think that it is great that we could get rid of Alzheimer’s due to how destructive it can be to the people that suffer it. But I think the other diseases that it can eliminate is horrible due to them making our world a more unique place such as people with autism, Down syndrome. By doing this it could eliminate the whole population of people with disabilities community and make everyone “normal”. Another bad that I found in the article Ethics of designer babies which states that a major flaw for these babies is “designer baby technologies suggest…arrow_forwardpick a specific disease that is currently a candidate for gene therapy—(a)briefly describing the gene mutation(s) and resulting disease symptoms, (b)brief description of a current gene therapy approach(es) for this disease. Has this approach shown any potential successes in disease treatment?arrow_forwardYou’ve made your construct and placed it into E. coli! Congratulations, you have made a transgenic organism. Your investors will want to know about quality control. How will you check that the correct piece of DNA is in your vector? How will you check to make sure the gene is transcribed? How will you check to make sure that the GasP protein is made in E. coli?arrow_forward
- In a clinical context, doctors are evaluating a therapy for a new patient (say patient B) that they have reasons to believe might develop a cancer similar to another patient they treated successfully (patient A). They know that the severity of the cancer is mainly associated with mutations in a specific gene (BRCAI). Suggest a technique that can be used to rapidly assess the similarity between the genetic panerns of patients A and B, without the need to sequence the entire gene, and briefly describe it. A team of scientists are interested in the amplification of a specific DNA fragment in a large plasmid of about 10000 bps. (0) (11) The sequence the scientists are interested in is 5'-CATTGATTATTG[...JATCAATTACGGG-3" 3-GTAACTAATAAG[...]TAGTTAATGCCC-5* Where [...] indicates a longer 100bps sequence. Provide two possible primers that the scientists should use to address their need, if they want to be sure they specifically address this region in the entire plasmid. Briefly explain the…arrow_forwardBecause genetic engineering involves the modification of an organism's set of instructions, it has created a dilemma raising both moral and ethical concerns. For instance, a biotechnological company has found a way to produce rice that is immune to pests and diseases, which is vital for the establishment of food security. However, the methods that will be implemented are by splicing off the genes of endangered pandas using invasive procedures that may harm their population. Will you support this? Why or why not? Limit your answers to 5 sentences or less. Be brief and concise.arrow_forwardAlthough it is well known that X-rays cause mutations, they are routinely used to diagnose medical problems, including potential tumors, broken bones, and dental cavities. Why is this done? What precautions need to be taken?arrow_forward
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