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16-59 Morphine and its O-methylated derivative, codeine, are among the most effective painkillers known. However, they possess two serious drawbacks: they are addictive, and repeated use induces a tolerance to the drug. Many morphine analogs have been prepared in an effort to find drugs that are equally effective as painkillers but that have less risk of physical dependence and potential abuse. Following are three of these.

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Introduction to General, Organic a...

11th Edition
Frederick A. Bettelheim + 4 others
Publisher: Cengage Learning
ISBN: 9781285869759
BuyFind

Introduction to General, Organic a...

11th Edition
Frederick A. Bettelheim + 4 others
Publisher: Cengage Learning
ISBN: 9781285869759

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Chapter
Section
Chapter 16, Problem 16.59P
Textbook Problem

16-59 Morphine and its O-methylated derivative, codeine, are among the most effective painkillers known. However, they possess two serious drawbacks: they are addictive, and repeated use induces a tolerance to the drug.

Chapter 16, Problem 16.59P, 16-59 Morphine and its O-methylated derivative, codeine, are among the most effective painkillers , example  1

Many morphine analogs have been prepared in an effort to find drugs that are equally effective as painkillers but that have less risk of physical dependence and potential abuse. Following are three of these.

Chapter 16, Problem 16.59P, 16-59 Morphine and its O-methylated derivative, codeine, are among the most effective painkillers , example  2

Chapter 16, Problem 16.59P, 16-59 Morphine and its O-methylated derivative, codeine, are among the most effective painkillers , example  3

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Chapter 16 Solutions

Introduction to General, Organic and Biochemistry
Show all chapter solutions
Ch. 16 - 16-11 Draw a structural formula for each amine...Ch. 16 - 16-12 Draw a structural formula for each amine....Ch. 16 - 16-13 Classify each amino group as primary,...Ch. 16 - 16-14 There are eight constitutional isomers with...Ch. 16 - 16-15 There are eight primary amines with the...Ch. 16 - 16-16 Answer true or false. Hydrogen bonding...Ch. 16 - 16-17 Propylamine (bp 48°C), ethylmethylamine (bp...Ch. 16 - 16-18 Account for the fact that 1-butanamine (bp...Ch. 16 - 16-19 2-Me thy 1 propane (bp -12°C), 2-propanol...Ch. 16 - 16-20 Account for the fact that most...Ch. 16 - 16-21 Answer true or false. (a, Aqueous solutions...Ch. 16 - 16-22 Compare the base strengths of amines with...Ch. 16 - 16-23 Write a structural formula for each amine...Ch. 16 - Prob. 16.24PCh. 16 - Prob. 16.25PCh. 16 - 16-26 The p/fb of amphetamine is approximately 3.2...Ch. 16 - 16-27 Guanidine, p/Ca 13.6, is a very strong base,...Ch. 16 - 16-28 Following is the structural formula of...Ch. 16 - 16-29 Suppose you have two test tubes, one...Ch. 16 - Prob. 16.30PCh. 16 - 16-31 Pyridoxamine is one form of vitamin B6....Ch. 16 - 16*32 Many tumors of the breast are correlated...Ch. 16 - 16-33 (Chemical Connections 16A) What are the...Ch. 16 - 16-34 (Chemical Connections 16A) What are the...Ch. 16 - 16-35 (Chemical Connections 16B ) What is an...Ch. 16 - 16-36 (Chemical Connections 16B) Identify all...Ch. 16 - 16-37 (Chemical Connections 16B) Which of the two...Ch. 16 - 16-38 (Chemical Connections 16B) Cocaine has four...Ch. 16 - 16-39 (Chemical Connections 160 What structural...Ch. 16 - 16-40 (Chemical Connections 16C) Is Librium...Ch. 16 - 16-41 (Chemical Connections 16C) Benzodiazepines...Ch. 16 - 16-42 (Chemical Connections 16D>Suppose you saw...Ch. 16 - 16-43 (Chemical Connections 16D) Give two reasons...Ch. 16 - 16-44 (Chemical Connections 16E) Classify each...Ch. 16 - 16-45 Draw a structural formula for a compound...Ch. 16 - 16-46 Arrange these three compounds in order of...Ch. 16 - 16-47 Consider these three compounds: CH3OH,...Ch. 16 - 16-48 Arrange these compounds in order of...Ch. 16 - 16-49 Account for the fact that amines have about...Ch. 16 - 16-50 If you dissolve CH3CH.2CR2OH and...Ch. 16 - 16-51 The compound phenylpropanolamine...Ch. 16 - Is procaine chiral? Does it contain a...Ch. 16 - 16-53 Following are two structural formulas for...Ch. 16 - 16-54 Several poisonous plants, including Atropa...Ch. 16 - 16-55 Epibatadine, a colorless oil isolated from...Ch. 16 - 16-56 Following are two structural formulas for...Ch. 16 - 16-57 Alanine, C3H7O2N, is one of the 20 amino...Ch. 16 - 16-58 Following is a structural formula of...Ch. 16 - 16-59 Morphine and its O-methylated derivative,...

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