Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
7th Edition
ISBN: 9781464126116
Author: David L. Nelson, Michael M. Cox
Publisher: W. H. Freeman
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Chapter 16, Problem 28P
Summary Introduction

To explain: How the activity of the citrate synthase is regulated by succinyl CoA, on the basis of the graph given.

Introduction:

Citrate synthase is found in almost all the living cells. This enzyme functions as the catalyst in the citric acid cycle. Citric acid is found in mitochondrial matrix of eukaryotic cells but it is not encoded by mitochondrial DNA instead it is encoded by nuclear DNA. Succinyl CoA resembles acetyl CoA in structure and it inhibits the activity of the enzyme citric acid synthase.

Summary Introduction

To explain: Why succinyl CoA is a suitable indicator for the regulation of citric acid cycle.

Introduction:

Succinyl CoA is a competitive inhibitor of acetyl CoA. Acetyl CoA is responsible for the activity of the enzyme citrate synthase. Increased concentration of succinyl CoA decreases the amount of acetyl CoA, hence activity of citrate synthase is regulated.

Summary Introduction

To explain: How the rate of cellular respiration in pig heart tissue is controlled by regulation of citrate synthase.

Introduction:

Citric acid cycle is a type of cellular respiration which takes place in the mitochondrial matrix. Citric acid cycle is an aerobic cellular respiration which requires oxygen for proper functioning.

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Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY