Concept explainers
Interpretation:
The best described rearrangement step in the given reaction is to be predicted.
Concept introduction:
In some
Epoxide opening reactions are facilitated by Lewis acids such as boron trifluoride (
In the first step, the
In the second step, the migration of a group takes place which is assisted by electron-pair donation from the epoxide oxygen.
In the next step, subsequent deprotonation occurs to yield an
For an equally substituted epoxide, the aryl group prefers to migrate over the hydrogen atom.
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Organic Chemistry - Standalone book
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- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning