The use of haplotype mapping to find the effectiveness of a drug in a patient. Introduction: The study of the effectiveness of the drug based on information about individual genome is called pharmacogenomics. Haplotype mapping is the identification of single nucleotide polymorphism (SNP) present in the human genome.

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Go to the NCBI’s website at https://ncbi.nlm.nih.gov On the database dropdown menu, select “Gene” and search for “RB1.” The first entry should be on the Homo sapiens version; click the gene name. Use the information to answer the following: What is the chromosomal location of RB1? Scroll down to the “Expression” data. List 2-3 examples of normal tissues that typically express the RB1 gene. Would you say that RB1 expression is very specific or general within tissues? Scroll down to the “NCBI Reference Sequences (RefSeq)” section. Click on the “GenBank” link under NG_009009.1 RefSeqGene. This will take you to the genomic sequence of RB1. How many nucleotides long is the full-length RB1 gene? Return to the RefSeq section in the Gene Database for RB1 (back click once from where you were for part c). Click on the link under “mRNA and Protein(s)” listed as NM_000321.3. This will take you to the mature mRNA sequence data: How many bases long is the full-length RB1 mRNA transcript? Scroll…

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Chapter 17.4, Problem 2R

Summary Introduction

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The use of haplotype mapping to find the effectiveness of a drug in a patient.

Introduction:

The study of the effectiveness of the drug based on information about individual genome is called pharmacogenomics. Haplotype mapping is the identification of single nucleotide polymorphism (SNP) present in the human genome.

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Go to the NCBI’s website at https://ncbi.nlm.nih.gov On the database dropdown menu, select “Gene” and search for “RB1.” The first entry should be on the Homo sapiens version; click the gene name. Use the information to answer the following: What is the chromosomal location of RB1? Scroll down to the “Expression” data. List 2-3 examples of normal tissues that typically express the RB1 gene. Would you say that RB1 expression is very specific or general within tissues? Scroll down to the “NCBI Reference Sequences (RefSeq)” section. Click on the “GenBank” link under NG_009009.1 RefSeqGene. This will take you to the genomic sequence of RB1. How many nucleotides long is the full-length RB1 gene? Return to the RefSeq section in the Gene Database for RB1 (back click once from where you were for part c). Click on the link under “mRNA and Protein(s)” listed as NM_000321.3. This will take you to the mature mRNA sequence data: How many bases long is the full-length RB1 mRNA transcript? Scroll…

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