ORGANIC CHEMISTRY
5th Edition
ISBN: 9781259977596
Author: SMITH
Publisher: MCG
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Textbook Question
Chapter 18, Problem 18.42P
Draw the structure of A, an intermediate in the synthesis of the antipsychotic drug risperidone. Explain why three rings in risperidone are considered
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12) Which compound is stronger base?
a)
b) D
A
d) all the same
Classify each compound as aromatic, antiaromatic, or not aromatic.
The order of increasing acidity is
Phenol < meta-cyanophenol < ortho-cyanophenol
1.how about para-cyanophenol??does it has higher acidicity than both ortho-cyanophenol and meta cyanophenol or lower??
2.why does ortho-cyanophenol have higher acidicity than meta cyanophenol??
3. why doesmeta cyanophenol have higher acidicity than Phenol
Chapter 18 Solutions
ORGANIC CHEMISTRY
Ch. 18 - Prob. 18.1PCh. 18 - Prob. 18.2PCh. 18 - Prob. 18.3PCh. 18 - Prob. 18.4PCh. 18 - Prob. 18.5PCh. 18 - Prob. 18.6PCh. 18 - Prob. 18.7PCh. 18 - Prob. 18.8PCh. 18 - Problem 18.9 Draw the product of each reaction
a....Ch. 18 - Prob. 18.10P
Ch. 18 - Prob. 18.11PCh. 18 - Prob. 18.12PCh. 18 - Prob. 18.13PCh. 18 - Problem 18.14 Draw all resonance structures for...Ch. 18 - Problem 18.15 Classify each substituent as...Ch. 18 - Prob. 18.16PCh. 18 - Problem 18.17 Label each compound as more or less...Ch. 18 - Problem 18.18 Rank the following compounds in...Ch. 18 - Prob. 18.19PCh. 18 - Problem 18.20 Draw the products of each...Ch. 18 - Prob. 18.21PCh. 18 - Problem 18.22 Draw the products formed when each...Ch. 18 - Problem 18.23 Devise a synthesis of each compound...Ch. 18 - Problem 18.24 Draw the products of each...Ch. 18 - Problem 18.25 Draw a stepwise mechanism for the...Ch. 18 - Problem 18.26 Draw the products of each...Ch. 18 - Prob. 18.27PCh. 18 - Prob. 18.28PCh. 18 - Problem 18.29 How could you use ethylbenzene to...Ch. 18 - Prob. 18.30PCh. 18 - Problem 18.31 What steps are needed to convert...Ch. 18 - Problem 18.32 Synthesize each compound from...Ch. 18 - Problem 18.33 Synthesize each compound from...Ch. 18 - Prob. 18.34PCh. 18 - 18.35 What is the major product formed by an...Ch. 18 - 18.36 Draw the products formed when phenol is...Ch. 18 - Problem 18.37 Draw the products formed when each...Ch. 18 - 18.38 Draw the products of each reaction.
a. d....Ch. 18 - 18.39 What products are formed when benzene is...Ch. 18 - 18.40 Draw the products of each reaction.
c.
d....Ch. 18 - 18.41 You have learned two ways to make an alkyl...Ch. 18 - 18.42 Draw the structure of A, an intermediate in...Ch. 18 - Prob. 18.43PCh. 18 - Prob. 18.44PCh. 18 - 18.45 Explain why each of the following reactions...Ch. 18 - Prob. 18.46PCh. 18 - 18.47 For each of the following substituted...Ch. 18 - 18.48 Consider the tetracyclic aromatic compound...Ch. 18 - 18.49 For each N-substituted benzene, predict...Ch. 18 - Prob. 18.50PCh. 18 - 18.51 Using resonance structures, explain why a...Ch. 18 - Prob. 18.52PCh. 18 - 18.53 Rank the aryl halides in each group in order...Ch. 18 - 18.54 Draw a stepwise mechanism for the following...Ch. 18 - Prob. 18.55PCh. 18 - 18.56 Draw a stepwise, detailed mechanism for the...Ch. 18 - Prob. 18.57PCh. 18 - 18.58 Draw a stepwise mechanism for the following...Ch. 18 - Prob. 18.59PCh. 18 - Prob. 18.60PCh. 18 - Prob. 18.61PCh. 18 - Prob. 18.62PCh. 18 - 18.63 Synthesize each compound from benzene and...Ch. 18 - Problem 18.64 Synthesize each compound from...Ch. 18 - Prob. 18.65PCh. 18 - Prob. 18.66PCh. 18 - Prob. 18.67PCh. 18 - Prob. 18.68PCh. 18 - Problem 18.69 Identify the structures of isomers A...Ch. 18 - Prob. 18.70PCh. 18 - Problem 18.71 Compound X (molecular formula ) was...Ch. 18 - 18.72 Reaction of p-cresol with two equivalents of...Ch. 18 - Prob. 18.73PCh. 18 - The NMR spectrum of phenol () shows three...Ch. 18 - Explain the reactivity and orientation effects...Ch. 18 - Prob. 18.76PCh. 18 - Prob. 18.77PCh. 18 - Prob. 18.78PCh. 18 - Prob. 18.79P
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- Draw the structure of A, an intermediate in the synthesis of theantipsychotic drug risperidone. Explain why three rings in risperidone are considered aromatic.arrow_forwardWhich heterocycles are aromatic?arrow_forwarda) Explain using resonance why electrophilic aromatic substitution of pyrrole occur at a-position.arrow_forward
- What steps are needed to convert A to B?arrow_forwardDraw the structure of A, an intermediate in the synthesis of the antipsychotic drug risperidone. Explain why three rings in risperidone are considered aromatic.arrow_forwarda) Draw all resonance forms of 3-hydroxybenzaldehyde and of the corresponding conjugate base. W hich conclusions can you draw for its acidity (pKa) in comparison to phenol?| b) Draw all resonance forms of 3-hydroxybenzaldehyde and of the corresponding conjugate base. Which conclusions can you draw for its acidity (pKa) in comparison to phenol and 3-hydroxybenzaldehyde? c) Discuss the relative acidities of 2-hydroxybenzaldehyd und 4-hydroxybenzaldehyd.arrow_forward
- Varenicline (trade name Chantix) is a drug used to help smokers quit their habit. (a) Which N atom in varenicline is most basic? Explain your choice. (b) What product is formed when varenicline is treated with HCl?arrow_forwardExplain whether the following compounds are aromatic or not. а. b. С. d. N.arrow_forwardAnswer the following question about esmolol (attached) , a drug used to treat high blood pressure sold under the trade name Brevibloc. Question: What products are formed when esmolol is treated with NaH?arrow_forward
- Draw all possible resonance structures for the antihistamine diphenhydramine, the active ingredient in Benadryl.arrow_forwardwhy pyrazole is more basic than pyridine?arrow_forwardDecide which N atom in each molecule is most basic, and draw theproduct formed when each compound is treated with CH3CO2H.Zolpidem (trade name Ambien) is used to treat insomnia, whereasaripiprazole (trade name Abilify) is used to treat depression,schizophrenia, and bipolar disorders.arrow_forward
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