Pearson eText Genetic Analysis: An Integrated Approach -- Instant Access (Pearson+)
Pearson eText Genetic Analysis: An Integrated Approach -- Instant Access (Pearson+)
3rd Edition
ISBN: 9780135564172
Author: Mark Sanders, John Bowman
Publisher: PEARSON+
bartleby

Concept explainers

bartleby

Videos

Textbook Question
Book Icon
Chapter 18, Problem 20P

A powerful approach to identifying genes of a developmental pathway is to screen for mutations that suppress or enhance the phenotype of interest. This approach was undertaken to elucidate the genetic pathway controlling C. elegansvulval development.

a. A lin-3 loss of function mutant with a vulva less phenotype was mutagenized. Based on your knowledge of the genetic pathway, what types of mutations will suppress the vulva less phenotype?

b. In a complementary experiment, a gain of function let-23 mutant with a multi vulva phenotype was also mutagenized. What types of mutations will suppress the multi vulva phenotype?

Blurred answer
Students have asked these similar questions
With the understanding of DNA methylation and gene expression, answer these following questions with as little word as possible. a. What is the difference between a CpG Island vs a CpG-poor region of the genome? b. What is the typical effect of 5mCpG on gene expression, and what two classes of DNA sequences are most heavily methylated? c. What is sex-specific genomic imprinting? Cite at least one example with the given example. d. What is the main function of HOX genes: specifically, the ANT-C  vs. the BX-C clusters?
The ability to selectively modify the genome in the mouse has revolutionized mouse genetics. Outline the procedure for generating a knockout mouse at a specific genetic locus. How can the loxP-Cre system be used to conditionally knock out a gene? What is an important medical application of knockout mice?
a. Describe two ways you could potentially make atransgene that would inhibit the function of a specific gene in a transgenic organism. (Hint: For oneof these techniques, recall the discussion of RNAinterference in Chapter 17.)b. Discuss how you could use either of these methodsto construct a mouse model for a recessive humangenetic condition associated with a loss of function, such as cystic fibrosis.

Chapter 18 Solutions

Pearson eText Genetic Analysis: An Integrated Approach -- Instant Access (Pearson+)

Knowledge Booster
Background pattern image
Biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY