(a)
Interpretation:
The use of amine synthesis for the conversion of allybromide to allylamine is to be shown.
Concept introduction:
The Gabriel synthesis is used for the preparation of primary
(b)
Interpretation:
The use of amine synthesis for the conversion of ethylbenzene to
Concept introduction:
The Gabriel synthesis is used for the preparation of primary amines. It is also called Gabriel phthalimide synthesis. In this synthesis
(c)
Interpretation:
The use of amine synthesis for the conversion of
Concept introduction:
The Gabriel synthesis is used for the preparation of primary amines. It is also called Gabriel phthalimide synthesis. In this synthesis
(d)
Interpretation:
The use of amine synthesis for the conversion of
Concept introduction:
The Gabriel synthesis is used for the preparation of primary amines. It is also called Gabriel phthalimide synthesis. In this synthesis
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Organic Chemistry (9th Edition)
- Which of these statements is NOT true about the reaction of amines with a cyclic anhydride like phthalic anhydride? a. Dimethylamine will give a cyclic imide product. b. Aniline will give a cyclic imide product. c. Triethylamine will give a cyclic imide product. d. The reaction undergoes a nucleophilic acyl substitution mechanism.arrow_forwardThree of the following amines can be prepared by the Gabriel synthesis; three cannot. Write equations showing the successful applications of this method. (a) Butylamine (b) Isobutylamine (c) tert-Butylamine (d) 2-Phenylethylamine (e) N-Methylbenzylamine (f) Anilinearrow_forwardgive the results of the following compounds after reaction with nitrous acid test a. primary aliphatic amine b. secondary aliphatic amine c. tertiary aliphatic amine d. primary aromatic aminearrow_forward
- Primary amines can also be prepared by the reaction of an alkyl halide with azide ion, followed by catalytic hydrogenation. What advantage do this method and the Gabriel synthesis have over the synthesis of a primaryamine using an alkyl halide and ammonia?arrow_forward1. Write the observations and results when (a)Fumaric Acid is reacted with Sodium Hydroxide,(b)when reacted with Sodium Bicarbonate. Write also the reaction equations. 2. Solubility of Amines in AcidPut 2 ml of water in a 10x75-mm test tube. Add 5 to 10 drops of aniline. Add 6 N hydrochloric acid dropwise until the aniline dissolves. Then add 6 N sodium hydroxide until the aniline reappears. Write the observations/results in this experiment and the reaction equation.arrow_forwardTreatment of pentanedioic (glutaric) anhydride with ammonia at elevated temperature leads to a compound of molecular formula C5H7NO2. What is the structure of this product? [Hint: You need to think about the reactivity not only of acid anhydrides but also of amides and carboxylic acids]arrow_forward
- What must be the starting material to carry out the following reaction? a) butanamide b) 4-aminobutanol c) 1-amino-2-butanone d) propanamide e) butanenitrilearrow_forwardShow how to synthesize the following amines from the indicated starting materials below. Each of the final products may require several sequential steps. Draw the structure for each of the steps and show the reagents required. Starting material Final product b) Benzene m-bromoaniline c) ethylbenzene p-ethylaniline + o-ethylaniline d) benzene p-bromoaniline + o-bromoanilinearrow_forwardGive the products expected when the following tertiary amines are treated with a peroxyacid and heated.(a) N,N-dimethylhexan-2-aminearrow_forward
- A. The water solubility of amines found in medications can be increased by salt formation. Dextromethorphan hydrobromide, a cough suppresant, is the salt formed from dextromethorphan (XX) and hydrobromic acid (HBr). Write the equation for the formation of dextromethorphan hydrobromide. B. Suggest appropriate starting materials ( amine and alkyl halide) needed for the preparation of each of the following salts: 1. Cetylpyridinium chloride 2. Benzyldimethyltetradecylammonium chloridearrow_forwardWhy are diazonium salts of aromatic amines more stable than those of aliphatic amines?arrow_forward1. outline a procedure for separating a mixture of naphthalene (a neutral compound), toluic acid (an acidic compound), and p-bromoaniline (a basic compound). Assume that toluic acid and p-bromoaniline are completely insoluble in water. 2. The solubility of Lorazepam (a tranquilizer found in Emotival , Lorax, Wypax, and other prescription medicines) is 0.08mg/mL and 2.62mg/mL, in water and chloroform, respectively. Estimate the partition coefficient of lorazepam between chloroform and water. 3. The solubility of benzoic acid at 25 degrees Celsius in water and diethyl ether is 3.35 mg/mL and 0.353 g/mL, respectively. Estimate the percent recovery of benzoic acid in the organic phase, if a solution of benzoic acid in water is extracted with an equivalent volume of ether. [HINT-pay attention to the units] 4. The solubilities of cholesterol in water and chloroform are 0.550mg/100mL and 1.00g/5.25mL, respectively. Estimate the partition coefficient of cholesterol between chloroform and…arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning