(a)
To describe: The synthesis of the given amine from the indicated starting material by reductive amination.
Interpretation: The synthesis of the given amine from the indicated starting material by reductive amination is to be described.
Concept introduction: The organic compounds which contain the
(b)
To describe: The synthesis of the given amine from the indicated starting material by reductive amination.
Interpretation: The synthesis of the given amine from the indicated starting material by reductive amination is to be described.
Concept introduction: The organic compounds which contain the functional groups containing a nitrogen atom with a lone pair of electrons are amines. Amines are the derivatives of ammonia. They have more than one hydrogen atoms. These hydrogen atoms can replace with an alkyl or aryl group. Amines can act as both bases and nucleophiles due to the unshared electron pair.
(c)
To describe: The synthesis of the given amine from the indicated starting material by reductive amination.
Interpretation: The synthesis of the given amine from the indicated starting material by reductive amination is to be described.
Concept introduction: The organic compounds which contain the functional groups containing a nitrogen atom with a lone pair of electrons are amines. Amines are the derivatives of ammonia. They have more than one hydrogen atoms. These hydrogen atoms can replace with an alkyl or aryl group. Amines can act as both bases and nucleophiles due to the unshared electron pair.
(d)
To describe: The synthesis of the given amine from the indicated starting material by reductive amination.
Interpretation: The synthesis of the given amine from the indicated starting material by reductive amination is to be described.
Concept introduction: The organic compounds which contain the functional groups containing a nitrogen atom with a lone pair of electrons are amines. Amines are the derivatives of ammonia. They have more than one hydrogen atoms. These hydrogen atoms can replace with an alkyl or aryl group. Amines can act as both bases and nucleophiles due to the unshared electron pair.
(e)
To describe: The synthesis of the given amine from the indicated starting material by reductive amination.
Interpretation: The synthesis of the given amine from the indicated starting material by reductive amination is to be described.
Concept introduction: The organic compounds which contain the functional groups containing a nitrogen atom with a lone pair of electrons are amines. Amines are the derivatives of ammonia. They have more than one hydrogen atoms. These hydrogen atoms can replace with an alkyl or aryl group. Amines can act as both bases and nucleophiles due to the unshared electron pair.
(f)
To describe: The synthesis of the given amine from the indicated starting material by reductive amination.
Interpretation: The synthesis of the given amine from the indicated starting material by reductive amination is to be described.
Concept introduction: The organic compounds which contain the functional groups containing a nitrogen atom with a lone pair of electrons are amines. Amines are the derivatives of ammonia. They have more than one hydrogen atoms. These hydrogen atoms can replace with an alkyl or aryl group. Amines can act as both bases and nucleophiles due to the unshared electron pair.
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Chapter 19 Solutions
Organic Chemistry (9th Edition)
- Why do you wash the dichloromethane solution of your reductive amination product with sodium bicarbonate, rather than dilute aqueous HCl? a) Sodium bicarbonate is a good method of removing aldehydes from organic solvent.b) The amine product will be protonated by acid and remain in the aqueous layer as a salt.c) Sodium bicarbonate transfers the amine starting material into the aqueous layer.d) Sodium bicarbonate reacts with leftover NaBH(OAc)3 and removes it from the mixture.arrow_forwardShow how to synthesize the following amines from the indicated starting materials byreductive amination. cyclohexylamine from cyclohexanonearrow_forwardShow how to convert amines to other functional groups, and devise multistepsyntheses using amines as starting materials and intermediatesarrow_forward
- Excess ammonia must be used when a primary amine is synthesized by reductive amination. What product will be obtained if the reaction is carried out with excess carbonyl compound?arrow_forwardShow how to synthesize the following amines from the indicated starting materials byreductive amination. ) N-cyclohexylaniline from cyclohexanonearrow_forwardShow how to synthesize the following amines from the indicated starting materials.(a) N-cyclopentylaniline from aniline (b) N-ethylpyrrolidine from pyrrolidinearrow_forward
- Synthesis of p-Bromoaniline Why is the protection of the amine function needed in this reaction? a) The protection increases the selectivity for the ortho substitution. b) The protection increases the reactivity of the reactant in the bromination. c) The protection changes the regioselectivity of reaxtion.arrow_forwardgive the results of the following compounds after reaction with nitrous acid test a. primary aliphatic amine b. secondary aliphatic amine c. tertiary aliphatic amine d. primary aromatic aminearrow_forwardWhat is the main reaction mechanism for this reductive amination?arrow_forward
- Illustrate the Separation of cyclohexanamine and cyclohexanol by an extraction procedure ?arrow_forwardWhat starting materials are needed to prepare attached drug using reductive amination? Give all possible pairs of compounds when more than one route is possible.arrow_forwardPrimary amines can also be prepared by the reaction of an alkyl halide with azide ion, followed by catalytic hydrogenation. What advantage do this method and the Gabriel synthesis have over the synthesis of a primaryamine using an alkyl halide and ammonia?arrow_forward
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