Biological Science (7th Edition)
7th Edition
ISBN: 9780134678320
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 19, Problem 8TYU
Summary Introduction
To review:
The effect of the mutation that caused continuous production of the active p53 on the cell.
Introduction:
P53 (molecular weight is 53 kilodaltons) is a protein, which is associated with the development of cancer in multicellular organisms. It prevents the formation of cancerous cells in the body. This protein is also considered as the “guardian of the genome.”
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List the regulatory mechanisms that might be lost in a cell producing faulty p53.
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Chapter 19 Solutions
Biological Science (7th Edition)
Ch. 19 - What is chromatin? a. the histone-containing...Ch. 19 - Prob. 4TYKCh. 19 - Compare and contrast the items in each pair: (a)...Ch. 19 - Prob. 6TYUCh. 19 - Prob. 8TYUCh. 19 - Prob. 9TYPSSCh. 19 - 10. QUANTITATIVE Imagine repeating the experiment...Ch. 19 - Prob. 12PIATCh. 19 - Prob. 13PIATCh. 19 - Prob. 14PIAT
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- Can you think of two ways in which the function of p53 can be disrupted?arrow_forwardName four downstream effects of p53 activation.arrow_forwardExplain the role of p53 protein in protecting normal cells against cancer. With respect to this protein and its function, explain how a normal cell turns cancerous.arrow_forward
- Post-translational control refers to: a. regulation of gene expression after transcription b. regulation of gene expression after translation c. control of epigenetic activation d. period between transcription and translationarrow_forwardWhat separates cancer cells from normal cells? Describe one form of mutation that can increase the risk of a normal cell being cancerous.arrow_forwardThe p53 gene encodes a tumor-suppressor protein, p53, which acts as a transcription factor for several genes. Discuss an example of a specific gene that is activated by p53 and how this gene activation will lead to a pause in the cell cycle for DNA repair to take place.arrow_forward
- Mutations in p53 are commonly associated with malignant tumor formation. Do deleterious mutations in p53 usually lead to a loss of function or gain of function of the protein?arrow_forwardp53 can trigger apoptosis if certain cell-cycle events fail. How does this regulatory outcome benefit a multicellular organism?arrow_forwardDescribe how tumor suppressors function to stop the cell cycle until certain events are completedarrow_forward
- A protein called p53 is another protein involved in controlling cell division. The protein p53 makes sure that if cells aren't functioning correctly, they don't divide anymore. Some people have damage to their p53 DNA and the protein isn't made correctly anymore. What might be a consequence if a person couldn't make the protein p53? A - Their cells would no longer use oxygen to make energy B - Their cells would no longer divide C - Their cells would make too much carbon dioxide D - Their cells could divide out of controlarrow_forwardexplain what are stem cellsarrow_forwardThe p53 pathway is important for regulating the cell cycle. In a normal cell, there is a protein called mdm2 that can bind to p53 and deactivate it. A diseased individual has amutation in the gene that codes for mdm2, resulting in an mdm2 protein that is less able to bind to p53. Will this mutation increase, decrease, or cause no change in the rate of cell death? Explain.arrow_forward
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