BIOLOGY:DYNAMIC SCIENCE-ACCESS >CUSTOM<
4th Edition
ISBN: 9781337254175
Author: Russell
Publisher: CENGAGE C
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Chapter 19.3, Problem 2SB
Summary Introduction
To review:
The way by which it can be determined that the steroid hormone affects the gene expression in human tissue culture cells.
Introduction:
Steroid hormones are the steroids that behave as hormones. They are grouped into two classes- corticosteroids and sex steroids. Their receptors are mostly intracellular with respect to the location, that is, they are present inside the cell. They can directly affect gene expression. The most studied steroid receptor is the nuclear receptor.
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Chapter 19 Solutions
BIOLOGY:DYNAMIC SCIENCE-ACCESS >CUSTOM<
Ch. 19.1 - What additional biological questions can be...Ch. 19.2 - What is the principle behind whole-genome shotgun...Ch. 19.2 - Prob. 2SBCh. 19.2 - Prob. 3SBCh. 19.2 - Prob. 4SBCh. 19.3 - Prob. 1SBCh. 19.3 - Prob. 2SBCh. 19.3 - Prob. 3SBCh. 19.4 - Prob. 1SBCh. 19.4 - Prob. 2SB
Ch. 19 - Prob. 1TYKCh. 19 - How do pseudogenes differ from genes? a. They are...Ch. 19 - Prob. 3TYKCh. 19 - Prob. 4TYKCh. 19 - Prob. 5TYKCh. 19 - Prob. 6TYKCh. 19 - About 95% of the average human transcription unit...Ch. 19 - Prob. 8TYKCh. 19 - Prob. 9TYKCh. 19 - When two protein-coding genes have very similar...Ch. 19 - Prob. 11TYKCh. 19 - Prob. 12TYKCh. 19 - Prob. 13TYKCh. 19 - Discuss Concepts The genome of the yeast...Ch. 19 - Prob. 15TYKCh. 19 - Prob. 16TYKCh. 19 - Prob. 17TYKCh. 19 - Below is a sequence of 540 bases from a genome....
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- Some hormones act by binding to the promoters of particular genes in such a way that RNA polymerase can attach much more easily to that gene. What effect would this have on whether or not the gene is “expressed”?arrow_forwardHow does an intracellular receptor regulate gene expression in the cell? Describe briefly what happens when a ligand like a hormone binds to one of these receptorsarrow_forwardHow would you produce a mouse that is homozygous fora rat growth-hormone transgene?arrow_forward
- Herceptin is an antibody that is used to treat certain forms of breast cancer by binding to a class of estrogen receptors. What is the basis for its effectiveness in treating certain forms of breast cancer?arrow_forwardList and discuss four different mechanisms by which vitamins A and D regulate gene expression.arrow_forwardWhy is recombinant Insulin produced by genetic engineering need to be processed?arrow_forward
- Through recombinant DNA methods, a modified steroid hormone receptor was prepared that consists of an estrogen receptor with its ligand-binding domain replaced by the ligandbinding domain from the progesterone receptor. Predict the expected responsiveness of gene expression for cells treated with estrogen or with progesterone.arrow_forwardWhat transcriptional repressors do.arrow_forwardHow are mutations in histone acetylation (HAT) genes linked to cancer?arrow_forward
- Please answer What would you expect to observe if you engineered a chimeric nuclear receptor superfamily protein by replacing the middle domain of a vitamin D receptor with the middle domain of a cortisol receptor? A.No activation of gene expression in response to either vitamin D or cortisol. b. Expression of vitamin D-responsive genes when cells are exposed to cortisol. C. Nothing unusual. D. Expression of cortisol-responsive genes when cells are exposed to vitamin D.arrow_forwardWhich of the following statements is FALSE? The mammalian glucocorticoid receptor: awaits the steroid hormone at the cell surface and is internalized into the cytoplasm upon glucocorticoid binding. is a hormone-dependent transcription factor. may act as an activator or repressor of transcription depending on the promoter it acts on. is sequestered in the cytoplasm by HSP90 as long as the glucocorticoid is absent. does not require phosphorylation by protein kinase A to bind DNA.arrow_forwardWhich are the many steps that can occur at Regulation of Gene Expression?arrow_forward
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