BIOCHEMISTRY
9th Edition
ISBN: 2818440090622
Author: BERG
Publisher: MAC HIGHER
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Chapter 2, Problem 11P
Interpretation Introduction
Interpretation:
The graph of concentration versus pH for histidine should be determined and the structures of each individual species should be drawn.
Concept introduction:
The ionization of an amino acid depends on the pH. In acidic pH both amino group and carboxylate group are protonated. When pH increases, the
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A. Write the structure of the following peptide at pH 5.0 and calculate its net charge at this pH.
Asp-His-Tyr-Arg-Lys-Leu-Thr-Gln. Based on the pKa value of the ionizable groups.
B. A polypeptide consisting only of L-glutamate residues (poly-L-glutamate) may have a random coil or helical structure depending on pH.
Explain this behavior by indicating at what pH values the helical structure will be favored.
a. Suppose that you have the peptide Ala-Gly-Tyr-His-Leu and you treat it with FDNB and then 6M HCl. Draw the structures of all the products that you will have in solution (assume all reactions to go to completion).
Chapter 2 Solutions
BIOCHEMISTRY
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 5PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10P
Ch. 2 - Prob. 11PCh. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 29PCh. 2 - Prob. 30PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37P
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- R V. Phospholipids are the main structural lipids that comprise cellular and organellar membranes. One abundant phospholipid in bacterial cell membranes is phosphatidylethanolamine (PE), which has a generic structure shown on the right. Note that R1 R and R2 are representative alkyl chains of attached fatty acids, each having about 16 – 20 carbon atoms. a) The overall net charge in one PE molecule is: -2 -1 0 +1 +2 CH₂ Phosphatidylethanolamine (PE) -CH H₂C. b) The glycerophosphate backbone in PE is a: D-enantiomer c) The fatty acids are attached to PE via which type of bond? amine L-enantiomer racemic NH3 amide ester ether d) Draw the commonly used cartoon representation of one phospholipid molecule. Label the hydrophilic and hydrophobic parts.arrow_forwardK₁ = α [H+][A-] [HA] [A-] pH = pK+log [HA] 1-1 The Amino acid Arginine ionizes according to the scheme below. Calculate the isoelectric point of Arginine and the average charge on arginine when pH = 9.2. NH2 H C=N NH pka-2.17 -H' NH2 H C=N H NH PK-8.99 -H +H* H (CH2)3 H-N-C-COOH | H H +H* H (CH2)3 H-N-C-coo- H H Ans: 10.75; +0.38 NH2 NH2 H C=N C=N-H H NH PK-12.5 -H NH | +H* (CH2)3 H₂N-C-COO- | H III (CH2)3 H₂N-C COO- H IVarrow_forwardMacmillan Learning The graphs show a titration curve for the amino acid histidine. Label the fist curve with the major histidine species at each position. One histidine species will not be used. Label the second curve with the pKå values for the histidine functional groups and the isoelectric point (pI) of histidine. 14 12 10 8 HH pH 6 His [His] = [His] 2 His²- [His² +] = [His*] 0 0.0 0.5 1.0 Incorrect Answer 1.5 [OH-] (equivalents) Hisº His [His] = [His] 2.0 2.5 3.0 His² + Answer Bankarrow_forward
- Suppose you have a solution of a protein, which contains a specific Tyr residue that has an actual (measured) pKa of 8.8. The protein binds a ligand by several noncovalent interactions, one of which is a hydrogen bond in which the Tyr phenolic hydroxyl group must serve as a hydrogen bond donor. Calculate the percentage of the protein molecules in which that tyrosyl residue's phenolic hydroxyl group could serve as a hydrogen bond donor at pH 8.5arrow_forwardMacmillan Learning The graphs show a titration curve for the amino acid histidine. Label the fist curve with the major histidine species at each position. One histidine species will not be used. Label the second curve with the pKå values for the histidine functional groups and the isoelectric point (pI) of histidine. 14 12 10 pH 6 8 4 His²+ 2 His+ 0 0.0 0.5 1.0 Incorrect Answer His²- [His²+] = [His*] 1.5 [OH-] (equivalents) Hisº His [His]=[His] 2.0 2.5 3.0 Answer Bank [His+] = [His]arrow_forwardCan someone please explain this?arrow_forward
- Consider the phenolic hydroxyl group of a particular Tyr residue in a protein. Suppose the hydroxyl group in the unfolded protein in aqueous solution, where the group is exposed to H2O, has a pKa of 10.0. If that group is found in a hydrophobic environment in the interior of the protein when the protein is folded into its native tertiary structure, would you expect the pKa of the phenolic hydroxyl to be higher or lower in the folded protein interior than in H2O? Explain your reasoning.arrow_forwardDescription Please draw the structure of the 19 L-a-amino acids and proline in any form, as you prefer. You may want to use a letter-size sheet or larger, it's up to you. Guiding principle: You want to understand the differences among amino acids. Although you may want to only draw the R-group it's preferable to draw it along with the rest of the molecule (i.e., the Ca, the amino group and the carboxyl group). Here are some examples (your drawings should not limited to the following styles): H₂C NH₂ OH shutterstock.com-222977980 Alanine H H Proline OH %%% lysine a alamy stock photo Tryptophan HN NH₂ shutterstock.com-1819000134 QH COOH H₂N-C- H CH ₂ Phenylalanine H₂N NH dreamstime.com arginine NH₂ OHarrow_forwardCan you please help find the ph 9.5 of ser?arrow_forward
- please match all of themarrow_forwardidentify the amino acid described. state the name, one-letter abbreviation, and draw the structure at pH 12.0 a non-polar essential amino acid capable of donating 1 carbon moiety in metabolismarrow_forwarduse one-letter code for amino acid if needed what is the overall amino acid sequence?arrow_forward
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